Please use this identifier to cite or link to this item: doi:10.22028/D291-36706
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Title: Profiling of Alzheimer's disease related genes in mild to moderate vitamin D hypovitaminosis
Author(s): Grimm, Marcus O. W.
Lauer, Anna A.
Grösgen, Sven
Thiel, Andrea
Lehmann, Johannes
Winkler, Jakob
Janitschke, Daniel
Herr, Christian
Beisswenger, Christoph
Bals, Robert
Grimm, Heike S.
Hartmann, Tobias
Language: English
Title: The Journal of Nutritional Biochemistry
Volume: 67
Pages: 123-137
Publisher/Platform: Elsevier
Year of Publication: 2019
Free key words: Alzheimer’s disease
Vitamin D hypovitaminosis
Vitamin D receptor
Gene expression
Neurodegeneration
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: A vast majority of the elderly population shows a mild to moderate vitamin D deficiency. Besides the well-known function of vitamin D, vitamin D receptor is also expressed in brain and is discussed to regulate several genes. However very little is known whether genes are regulated, associated with Alzheimer’s disease (AD). Here we investigate 117 genes, known to be affected in AD, in mouse brain samples with a mild vitamin D hypovitaminosis comparable to the vitamin D status of the elderly population (20%–30% deficiency). The 117 genes include two positive controls, Nep and Park7, already known to be affected by both AD and vitamin D hypovitaminosis. The 25 most promising candidates were verified in a second independent mouse cohort, resulting in eleven genes further evaluated against three additional housekeeping genes. Three of the remaining eight significantly altered genes are involved in APP homeostasis (Snca, Nep, Psmb5), and each one gene in oxidative stress (Park7), inflammation (Casp4), lipid metabolism (Abca1), signal transduction (Gnb5) and neurogenesis (Plat). Our results tighten the link of vitamin D and AD and underline that vitamin D influences several genes also in brain, highlighting that a strong link not only to AD but also to other neurodegenerative diseases might exist.
DOI of the first publication: 10.1016/j.jnutbio.2019.01.015
URL of the first publication: https://www.sciencedirect.com/science/article/abs/pii/S0955286318306314
Link to this record: urn:nbn:de:bsz:291--ds-367069
hdl:20.500.11880/33350
http://dx.doi.org/10.22028/D291-36706
ISSN: 0955-2863
Date of registration: 8-Jul-2022
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
M - Neurologie und Psychiatrie
Professorship: M - Prof. Dr. Robert Bals
M - Prof. Dr. Tobias Hartmann
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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