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doi:10.22028/D291-36706
Title: | Profiling of Alzheimer's disease related genes in mild to moderate vitamin D hypovitaminosis |
Author(s): | Grimm, Marcus O. W. Lauer, Anna A. Grösgen, Sven Thiel, Andrea Lehmann, Johannes Winkler, Jakob Janitschke, Daniel Herr, Christian Beisswenger, Christoph Bals, Robert Grimm, Heike S. Hartmann, Tobias |
Language: | English |
Title: | The Journal of Nutritional Biochemistry |
Volume: | 67 |
Pages: | 123-137 |
Publisher/Platform: | Elsevier |
Year of Publication: | 2019 |
Free key words: | Alzheimer’s disease Vitamin D hypovitaminosis Vitamin D receptor Gene expression Neurodegeneration |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | A vast majority of the elderly population shows a mild to moderate vitamin D deficiency. Besides the well-known function of vitamin D, vitamin D receptor is also expressed in brain and is discussed to regulate several genes. However very little is known whether genes are regulated, associated with Alzheimer’s disease (AD). Here we investigate 117 genes, known to be affected in AD, in mouse brain samples with a mild vitamin D hypovitaminosis comparable to the vitamin D status of the elderly population (20%–30% deficiency). The 117 genes include two positive controls, Nep and Park7, already known to be affected by both AD and vitamin D hypovitaminosis. The 25 most promising candidates were verified in a second independent mouse cohort, resulting in eleven genes further evaluated against three additional housekeeping genes. Three of the remaining eight significantly altered genes are involved in APP homeostasis (Snca, Nep, Psmb5), and each one gene in oxidative stress (Park7), inflammation (Casp4), lipid metabolism (Abca1), signal transduction (Gnb5) and neurogenesis (Plat). Our results tighten the link of vitamin D and AD and underline that vitamin D influences several genes also in brain, highlighting that a strong link not only to AD but also to other neurodegenerative diseases might exist. |
DOI of the first publication: | 10.1016/j.jnutbio.2019.01.015 |
URL of the first publication: | https://www.sciencedirect.com/science/article/abs/pii/S0955286318306314 |
Link to this record: | urn:nbn:de:bsz:291--ds-367069 hdl:20.500.11880/33350 http://dx.doi.org/10.22028/D291-36706 |
ISSN: | 0955-2863 |
Date of registration: | 8-Jul-2022 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Innere Medizin M - Neurologie und Psychiatrie |
Professorship: | M - Prof. Dr. Robert Bals M - Prof. Dr. Tobias Hartmann |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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