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Titel: High Serum Bilirubin Levels, NT-pro-BNP, and Lactate Predict Mortality in Long-Term, Severely Ill Respiratory ECMO Patients
VerfasserIn: Kaestner, Franziska
Rapp, Daniel
Trudzinski, Franziska C.
Olewczynska, Nicole
Wagenpfeil, Stefan
Langer, Frank
Flaig, Monika
Wilkens, Heinrike
Bals, Robert
Klingele, Matthias
Lensch, Christian
Fähndrich, Sebastian
Lepper, Philipp M.
Sprache: Englisch
Titel: ASAIO Journal
Bandnummer: 64 (2018)
Heft: 2
Seiten: 232-237
Verlag/Plattform: Lippincott Williams & Wilkins
Erscheinungsjahr: 2017
Freie Schlagwörter: extracorporeal membrane oxygenation
mortality
bilirubin
lactate
N-terminal pro b-type natriuretic peptide
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Mortality in patients treated with extracorporeal membrane oxygenation (ECMO) is high. Therefore, it is crucial to better understand conditions that are associated with mortality in ECMO patients. In this retrospective analysis, we observed 51 patients treated with high-flow ECMO in 2013 and 2014 at our center. We recorded laboratory values and intensive care procedures. The hypothesis of bilirubin being a predictor of mortality during ECMO treatment was initially addressed. Therefore, laboratory values were obtained before initiation and at the time of highest bilirubin throughout the procedure. Receiver operating characteristic (ROC) curves and survival analysis were conducted. Our cohort consisted of patients with advanced age (median: 55 years; range: 22–76) and high mortality (26/51; 51%). Lactate, bilirubin, and NT-pro-BNP were significantly (p < 0.05) associated with mortality in univariable analyses. The cut-off values with highest Youden’s index were bilirubin ≥10 mg/dl, lactate ≥2.25 mmol/L, and NT-pro-BNP ≥11,500 pg/ml. A multivariable analysis, revealed an area under the curve (AUC) of 0.85 (95% confidence interval [CI]: 0.74–0.97), sensitivity of 0.79, and specificity of 0.91. Bilirubin, lactate, and NT-pro-BNP were associated with mortality during ECMO treatment. However, laboratory values were only evaluated at the time of peak bilirubin.
DOI der Erstveröffentlichung: 10.1097/MAT.0000000000000610
URL der Erstveröffentlichung: https://journals.lww.com/asaiojournal/Fulltext/2018/03000/High_Serum_Bilirubin_Levels,_NT_pro_BNP,_and.15.aspx
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-367051
hdl:20.500.11880/33349
http://dx.doi.org/10.22028/D291-36705
ISSN: 1058-2916
Datum des Eintrags: 8-Jul-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplemental Digital Content
In Beziehung stehendes Objekt: https://links.lww.com/ASAIO/A168
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Chirurgie
M - Innere Medizin
M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
Professur: M - Prof. Dr. Robert Bals
M - Prof. Dr. Stefan Wagenpfeil
M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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