Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen:
Volltext verfügbar? / Dokumentlieferung
doi:10.22028/D291-36705
Titel: | High Serum Bilirubin Levels, NT-pro-BNP, and Lactate Predict Mortality in Long-Term, Severely Ill Respiratory ECMO Patients |
VerfasserIn: | Kaestner, Franziska Rapp, Daniel Trudzinski, Franziska C. Olewczynska, Nicole Wagenpfeil, Stefan Langer, Frank Flaig, Monika Wilkens, Heinrike Bals, Robert Klingele, Matthias Lensch, Christian Fähndrich, Sebastian Lepper, Philipp M. |
Sprache: | Englisch |
Titel: | ASAIO Journal |
Bandnummer: | 64 (2018) |
Heft: | 2 |
Seiten: | 232-237 |
Verlag/Plattform: | Lippincott Williams & Wilkins |
Erscheinungsjahr: | 2017 |
Freie Schlagwörter: | extracorporeal membrane oxygenation mortality bilirubin lactate N-terminal pro b-type natriuretic peptide |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Mortality in patients treated with extracorporeal membrane oxygenation (ECMO) is high. Therefore, it is crucial to better understand conditions that are associated with mortality in ECMO patients. In this retrospective analysis, we observed 51 patients treated with high-flow ECMO in 2013 and 2014 at our center. We recorded laboratory values and intensive care procedures. The hypothesis of bilirubin being a predictor of mortality during ECMO treatment was initially addressed. Therefore, laboratory values were obtained before initiation and at the time of highest bilirubin throughout the procedure. Receiver operating characteristic (ROC) curves and survival analysis were conducted. Our cohort consisted of patients with advanced age (median: 55 years; range: 22–76) and high mortality (26/51; 51%). Lactate, bilirubin, and NT-pro-BNP were significantly (p < 0.05) associated with mortality in univariable analyses. The cut-off values with highest Youden’s index were bilirubin ≥10 mg/dl, lactate ≥2.25 mmol/L, and NT-pro-BNP ≥11,500 pg/ml. A multivariable analysis, revealed an area under the curve (AUC) of 0.85 (95% confidence interval [CI]: 0.74–0.97), sensitivity of 0.79, and specificity of 0.91. Bilirubin, lactate, and NT-pro-BNP were associated with mortality during ECMO treatment. However, laboratory values were only evaluated at the time of peak bilirubin. |
DOI der Erstveröffentlichung: | 10.1097/MAT.0000000000000610 |
URL der Erstveröffentlichung: | https://journals.lww.com/asaiojournal/Fulltext/2018/03000/High_Serum_Bilirubin_Levels,_NT_pro_BNP,_and.15.aspx |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-367051 hdl:20.500.11880/33349 http://dx.doi.org/10.22028/D291-36705 |
ISSN: | 1058-2916 |
Datum des Eintrags: | 8-Jul-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplemental Digital Content |
In Beziehung stehendes Objekt: | https://links.lww.com/ASAIO/A168 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Chirurgie M - Innere Medizin M - Medizinische Biometrie, Epidemiologie und medizinische Informatik |
Professur: | M - Prof. Dr. Robert Bals M - Prof. Dr. Stefan Wagenpfeil M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Es gibt keine Dateien zu dieser Ressource.
Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt.