Please use this identifier to cite or link to this item: doi:10.22028/D291-36679
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Title: Allergic airway inflammation induces migration of mast cell populations into the mouse airway
Author(s): Schmit, David
Le, Duc Dung
Heck, Sebastian
Bischoff, Markus
Tschernig, Thomas
Herr, Christian
Beisswenger, Christoph
Kobelt, Peter
Lepper, Phillipp Moritz
Chung, Kian Fan
Bals, Robert
Dinh, Quoc Thai
Language: English
Title: Cell and Tissue Research
Volume: 369
Issue: 2
Pages: 331–340
Publisher/Platform: Springer Nature
Year of Publication: 2017
Free key words: Mast cells
Allergic airway inflammation
Tryptase
Chymase
Neuroimmune Interaction
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Mast cells (MCs) and airway nerves play an important role in allergic asthma. However, little is known about the MCs and their interaction with airway nerves during allergic airway inflammation. This study aims to investigate the distribution and proliferation of MC populations in different lung compartments, along with the association of mast cells with nerve endings, using a house dust mite (HDM) model for allergic airway inflammation. BALB/c mice were exposed to HDM extract intranasally (25 μg/50 μl) for 5 consecutive days a week over 7 weeks. Immunofluorescence and Edu stains were used to examine the colocalisation of MCs and nerves and the proliferation of MCs, respectively. HDM treatment caused an increased migration of MCs into bronchi, alveolar parenchyma and airway vessels. The proportions of tryptase-chymase expressing MC (MCTC) increased significantly in the bronchi and the alveolar parenchyma but not in the vascular tissues, by allergic airway inflammation. The association of MCs with nerves was found only in the bronchi and there were no changes in comparison of controls to HDM-treated animals. The present study shows a strong migration of tryptase expressing MC (MCT) and MCTC into the bronchi and the alveolar parenchyma, as well as of MCT in the vascular compartment under HDM treatment. This supports the hypothesis that these mast cell populations may contribute to allergic airway inflammation.
DOI of the first publication: 10.1007/s00441-017-2597-9
URL of the first publication: https://link.springer.com/article/10.1007/s00441-017-2597-9
Link to this record: urn:nbn:de:bsz:291--ds-366797
hdl:20.500.11880/33322
http://dx.doi.org/10.22028/D291-36679
ISSN: 1432-0878
0302-766X
Date of registration: 7-Jul-2022
Faculty: M - Medizinische Fakultät
Department: M - Anatomie und Zellbiologie
M - Infektionsmedizin
M - Innere Medizin
Professorship: M - Prof. Dr. Robert Bals
M - Prof. Dr. Sören Becker
M - Prof. Dr. Carola Meier
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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