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doi:10.22028/D291-36541
Title: | Causative agents and antimicrobial resistance patterns of human skin and soft tissue infections in Bagamoyo, Tanzania |
Author(s): | Kazimoto, Theckla Abdulla, Salim Bategereza, Leah Juma, Omar Mhimbira, Francis Weisser, Maja Utzinger, Jürg von Müller, Lutz Becker, Sören L. |
Language: | English |
Title: | Acta Tropica |
Volume: | 186 |
Pages: | 102-106 |
Publisher/Platform: | Elsevier |
Year of Publication: | 2018 |
Free key words: | Antibiotic resistance Diagnosis Enterobacteriaceae Infection Staphylococcus aureus Tanzania |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Few epidemiological studies have been carried out to assess the aetiology and antimicrobial susceptibility patterns of pathogens giving rise to skin and soft tissue infections (SSTIs) in sub-Saharan Africa. In the present study from six healthcare facilities in Bagamoyo, Tanzania, wound swabs from outpatients with SSTIs were analysed by a suite of methods, including microbiological culture techniques, matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry and resistance testing. Among 185 patients with SSTIs, 179 (96.8%) swabs showed microbiological growth. In total, 327 organisms were found, of which 285 were of potential aetiological relevance. Staphylococcus aureus was the predominant pathogen (prevalence: 71.4%), followed by the Gram-negative bacteria Enterobacter cloacae complex (14.6%), Klebsiella pneumoniae (12.4%) and Pseudomonas aeruginosa (11.8%). While one out of three isolates of S. aureus showed resistance to macrolides, tetracyclines, cotrimoxazole and clindamycin, only a single methicillin-resistant S. aureus (MRSA) strain was found. In Gram-negative bacteria, resistance to ampicillin and cotrimoxazole was common, while extended-spectrum beta-lactamases were rarely detected (<1%). We conclude that S. aureus was the most frequently detected pathogen in community-acquired SSTIs in Bagamoyo, Tanzania. Resistance to commonly prescribed oral antibiotics was considerable, but multi-resistant strains were rarely encountered. Monitoring of antibiotic susceptibility patterns in SSTIs is important to provide specific data for tailoring treatment recommendations. |
DOI of the first publication: | 10.1016/j.actatropica.2018.07.007 |
URL of the first publication: | https://www.sciencedirect.com/science/article/abs/pii/S0001706X18305473 |
Link to this record: | urn:nbn:de:bsz:291--ds-365414 hdl:20.500.11880/33193 http://dx.doi.org/10.22028/D291-36541 |
ISSN: | 0001-706X |
Date of registration: | 22-Jun-2022 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Infektionsmedizin |
Professorship: | M - Prof. Dr. Sören Becker |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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