Please use this identifier to cite or link to this item: doi:10.22028/D291-36541
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Title: Causative agents and antimicrobial resistance patterns of human skin and soft tissue infections in Bagamoyo, Tanzania
Author(s): Kazimoto, Theckla
Abdulla, Salim
Bategereza, Leah
Juma, Omar
Mhimbira, Francis
Weisser, Maja
Utzinger, Jürg
von Müller, Lutz
Becker, Sören L.
Language: English
Title: Acta Tropica
Volume: 186
Publisher/Platform: Elsevier
Year of Publication: 2018
Free key words: Antibiotic resistance
Diagnosis
Enterobacteriaceae
Infection
Staphylococcus aureus
Tanzania
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Few epidemiological studies have been carried out to assess the aetiology and antimicrobial susceptibility patterns of pathogens giving rise to skin and soft tissue infections (SSTIs) in sub-Saharan Africa. In the present study from six healthcare facilities in Bagamoyo, Tanzania, wound swabs from outpatients with SSTIs were analysed by a suite of methods, including microbiological culture techniques, matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry and resistance testing. Among 185 patients with SSTIs, 179 (96.8%) swabs showed microbiological growth. In total, 327 organisms were found, of which 285 were of potential aetiological relevance. Staphylococcus aureus was the predominant pathogen (prevalence: 71.4%), followed by the Gram-negative bacteria Enterobacter cloacae complex (14.6%), Klebsiella pneumoniae (12.4%) and Pseudomonas aeruginosa (11.8%). While one out of three isolates of S. aureus showed resistance to macrolides, tetracyclines, cotrimoxazole and clindamycin, only a single methicillin-resistant S. aureus (MRSA) strain was found. In Gram-negative bacteria, resistance to ampicillin and cotrimoxazole was common, while extended-spectrum beta-lactamases were rarely detected (<1%). We conclude that S. aureus was the most frequently detected pathogen in community-acquired SSTIs in Bagamoyo, Tanzania. Resistance to commonly prescribed oral antibiotics was considerable, but multi-resistant strains were rarely encountered. Monitoring of antibiotic susceptibility patterns in SSTIs is important to provide specific data for tailoring treatment recommendations.
DOI of the first publication: 10.1016/j.actatropica.2018.07.007
URL of the first publication: https://www.sciencedirect.com/science/article/abs/pii/S0001706X18305473
Link to this record: urn:nbn:de:bsz:291--ds-365414
hdl:20.500.11880/33193
http://dx.doi.org/10.22028/D291-36541
ISSN: 0001-706X
Date of registration: 22-Jun-2022
Faculty: M - Medizinische Fakultät
Department: M - Infektionsmedizin
Professorship: M - Prof. Dr. Sören Becker
Collections:Die Universitätsbibliographie

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