Please use this identifier to cite or link to this item:
doi:10.22028/D291-36388
Title: | Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior |
Author(s): | Fang, Li-Pao Zhao, Na Caudal, Laura C. Chang, Hsin-Fang Zhao, Renping Lin, Ching-Hsin Hainz, Nadine Meier, Carola Bettler, Bernhard Huang, Wenhui Scheller, Anja Kirchhoff, Frank Bai, Xianshu |
Language: | English |
Title: | Nature Communications |
Volume: | 13 |
Issue: | 1 |
Publisher/Platform: | Springer Nature |
Year of Publication: | 2022 |
Free key words: | Glial progenitors Neuronal development Oligodendrocyte |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Cortical neural circuits are complex but very precise networks of balanced excitation and inhibition. Yet, the molecular and cellular mechanisms that form the balance are just beginning to emerge. Here, using conditional γ-aminobutyric acid receptor B1- deficient mice we identify a γ-aminobutyric acid/tumor necrosis factor superfamily member 12-mediated bidirectional communication pathway between parvalbumin-positive fast spiking interneurons and oligodendrocyte precursor cells that determines the density and function of interneurons in the developing medial prefrontal cortex. Interruption of the GABAergic signaling to oligodendrocyte precursor cells results in reduced myelination and hypoactivity of interneurons, strong changes of cortical network activities and impaired social cognitive behavior. In conclusion, glial transmitter receptors are pivotal elements in finetuning distinct brain functions. |
DOI of the first publication: | 10.1038/s41467-022-29020-1 |
URL of the first publication: | https://www.nature.com/articles/s41467-022-29020-1 |
Link to this record: | urn:nbn:de:bsz:291--ds-363882 hdl:20.500.11880/33034 http://dx.doi.org/10.22028/D291-36388 |
ISSN: | 2041-1723 |
Date of registration: | 8-Jun-2022 |
Description of the related object: | Supplementary information |
Related object: | https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-29020-1/MediaObjects/41467_2022_29020_MOESM1_ESM.pdf https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-29020-1/MediaObjects/41467_2022_29020_MOESM2_ESM.pdf https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-022-29020-1/MediaObjects/41467_2022_29020_MOESM3_ESM.pdf |
Faculty: | M - Medizinische Fakultät |
Department: | M - Anatomie und Zellbiologie M - Biophysik M - Physiologie |
Professorship: | M - Prof. Dr. Frank Kirchhoff M - Prof. Dr. Carola Meier M - Keiner Professur zugeordnet |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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File | Description | Size | Format | |
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s41467-022-29020-1.pdf | 7,33 MB | Adobe PDF | View/Open |
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