Please use this identifier to cite or link to this item: doi:10.22028/D291-36388
Title: Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior
Author(s): Fang, Li-Pao
Zhao, Na
Caudal, Laura C.
Chang, Hsin-Fang
Zhao, Renping
Lin, Ching-Hsin
Hainz, Nadine
Meier, Carola
Bettler, Bernhard
Huang, Wenhui
Scheller, Anja
Kirchhoff, Frank
Bai, Xianshu
Language: English
Title: Nature Communications
Volume: 13
Issue: 1
Publisher/Platform: Springer Nature
Year of Publication: 2022
Free key words: Glial progenitors
Neuronal development
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Cortical neural circuits are complex but very precise networks of balanced excitation and inhibition. Yet, the molecular and cellular mechanisms that form the balance are just beginning to emerge. Here, using conditional γ-aminobutyric acid receptor B1- deficient mice we identify a γ-aminobutyric acid/tumor necrosis factor superfamily member 12-mediated bidirectional communication pathway between parvalbumin-positive fast spiking interneurons and oligodendrocyte precursor cells that determines the density and function of interneurons in the developing medial prefrontal cortex. Interruption of the GABAergic signaling to oligodendrocyte precursor cells results in reduced myelination and hypoactivity of interneurons, strong changes of cortical network activities and impaired social cognitive behavior. In conclusion, glial transmitter receptors are pivotal elements in finetuning distinct brain functions.
DOI of the first publication: 10.1038/s41467-022-29020-1
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-363882
ISSN: 2041-1723
Date of registration: 8-Jun-2022
Description of the related object: Supplementary information
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Anatomie und Zellbiologie
M - Biophysik
M - Physiologie
Professorship: M - Prof. Dr. Frank Kirchhoff
M - Prof. Dr. Carola Meier
M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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