Please use this identifier to cite or link to this item: doi:10.22028/D291-36032
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Title: Insertion site of central venous catheter correlates with catheter-related infectious events in patients undergoing intensive chemotherapy
Author(s): Rixecker, Torben
Lesan, Vadim
Ahlgrimm, Manfred
Thurner, Lorenz
Bewarder, Moritz
Murawski, Niels
Christofyllakis, Konstantinos
Altmeyer, Sarah
Bick, Angelika
Stilgenbauer, Stephan
Bittenbring, Joerg Thomas
Kaddu-Mulindwa, Dominic
Language: English
Title: Bone Marrow Transplantation
Volume: 56
Issue: 1
Pages: 195–201
Publisher/Platform: Springer Nature
Year of Publication: 2020
Publikation type: Journal Article
Abstract: Patients undergoing intensive chemotherapy are usually in need for central venous catheters (CVC). Due to contradictory study results, relation of insertion site and CVC-associated complication rate in these patients is not clear. We therefore retrospectively analyzed CVC-related data of all patients undergoing intensive chemotherapy with high risk of febrile neutropenia according to NCCN criteria, who received a CVC at our bone marrow transplantation unit between May 2016 and December 2019. In total, 210 patients received 281 CVC. CVC were placed via either the subclavian-vein (SCV, n = 58; 20%) or the internal-jugular-vein (IJV, n = 223; 80%). Median duration of CVC-lifetime and neutropenic days per CVC were comparable between the two groups (IJV vs SCV: 23 days vs 21 days (p = 0.16) and 12 days vs 11 days (p = 0.65)). Both, time to CVC removal due to local inflammation and time to central line-associated bloodstream infection was significantly shorter in patients with SCV catheters (p = 0.013 and p = 0.045). CVC placed in the IJV were associated with significantly less catheter-related infectious events compared with CVC placed in the SCV. This difference was consistent across different subgroups including 88 patients undergoing allogeneic stem cell transplantation.
DOI of the first publication: 10.1038/s41409-020-01003-0
URL of the first publication:
Link to this record: hdl:20.500.11880/32828
ISSN: 1476-5365
Date of registration: 21-Apr-2022
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Prof. Dr. Stephan Stilgenbauer
M - Dr. med. Lorenz Thurner
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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