Please use this identifier to cite or link to this item:
doi:10.22028/D291-35777
Title: | Free energies of membrane stalk formation from a lipidomics perspective |
Author(s): | Poojari, Chetan S. Scherer, Katharina C. Hub, Jochen S. |
Language: | English |
Title: | Nature Communications |
Volume: | 12 |
Issue: | 1 |
Publisher/Platform: | Springer Nature |
Year of Publication: | 2021 |
Free key words: | Computational biophysics Membrane biophysics Membrane fusion Membrane lipids |
DDC notations: | 500 Science |
Publikation type: | Journal Article |
Abstract: | Many biological membranes are asymmetric and exhibit complex lipid composition, comprising hundreds of distinct chemical species. Identifying the biological function and advantage of this complexity is a central goal of membrane biology. Here, we study how membrane complexity controls the energetics of the first steps of membrane fusions, that is, the formation of a stalk. We first present a computationally efficient method for simulating thermodynamically reversible pathways of stalk formation at coarse-grained resolution. The method reveals that the inner leaflet of a typical plasma membrane is far more fusogenic than the outer leaflet, which is likely an adaptation to evolutionary pressure. To rationalize these findings by the distinct lipid compositions, we computed ~200 free energies of stalk formation in membranes with different lipid head groups, tail lengths, tail unsaturations, and sterol content. In summary, the simulations reveal a drastic influence of the lipid composition on stalk formation and a comprehensive fusogenicity map of many biologically relevant lipid classes. |
DOI of the first publication: | 10.1038/s41467-021-26924-2 |
Link to this record: | urn:nbn:de:bsz:291--ds-357771 hdl:20.500.11880/32621 http://dx.doi.org/10.22028/D291-35777 |
ISSN: | 2041-1723 |
Date of registration: | 17-Mar-2022 |
Description of the related object: | Supplementary information |
Related object: | https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-26924-2/MediaObjects/41467_2021_26924_MOESM1_ESM.pdf https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-26924-2/MediaObjects/41467_2021_26924_MOESM2_ESM.pdf https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-26924-2/MediaObjects/41467_2021_26924_MOESM3_ESM.pdf |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Physik |
Professorship: | NT - Prof. Dr. Jochen Hub |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
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s41467-021-26924-2.pdf | 3,89 MB | Adobe PDF | View/Open |
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