Please use this identifier to cite or link to this item: doi:10.22028/D291-35777
Title: Free energies of membrane stalk formation from a lipidomics perspective
Author(s): Poojari, Chetan S.
Scherer, Katharina C.
Hub, Jochen S.
Language: English
Title: Nature Communications
Volume: 12
Issue: 1
Publisher/Platform: Springer Nature
Year of Publication: 2021
Free key words: Computational biophysics
Membrane biophysics
Membrane fusion
Membrane lipids
DDC notations: 500 Science
Publikation type: Journal Article
Abstract: Many biological membranes are asymmetric and exhibit complex lipid composition, comprising hundreds of distinct chemical species. Identifying the biological function and advantage of this complexity is a central goal of membrane biology. Here, we study how membrane complexity controls the energetics of the first steps of membrane fusions, that is, the formation of a stalk. We first present a computationally efficient method for simulating thermodynamically reversible pathways of stalk formation at coarse-grained resolution. The method reveals that the inner leaflet of a typical plasma membrane is far more fusogenic than the outer leaflet, which is likely an adaptation to evolutionary pressure. To rationalize these findings by the distinct lipid compositions, we computed ~200 free energies of stalk formation in membranes with different lipid head groups, tail lengths, tail unsaturations, and sterol content. In summary, the simulations reveal a drastic influence of the lipid composition on stalk formation and a comprehensive fusogenicity map of many biologically relevant lipid classes.
DOI of the first publication: 10.1038/s41467-021-26924-2
Link to this record: urn:nbn:de:bsz:291--ds-357771
ISSN: 2041-1723
Date of registration: 17-Mar-2022
Description of the related object: Supplementary information
Related object:
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Prof. Dr. Jochen Hub
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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