Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen: doi:10.22028/D291-35478
Titel: COVID-19 and Intracranial Hemorrhage: A Multicenter Case Series, Systematic Review and Pooled Analysis
VerfasserIn: Schmidbauer, Moritz L.
Ferse, Caroline
Salih, Farid
Klingner, Carsten
Musleh, Rita
Kunst, Stefan
Wittstock, Matthias
Neumann, Bernhard
Schebesch, Karl-Michael
Bösel, Julian
Godau, Jana
Lochner, Piergiorgio
Adam, Elisabeth H.
Jahnke, Kolja
Knier, Benjamin
Schirotzek, Ingo
Müllges, Wolfgang
Notz, Quirin
Dengl, Markus
Güldner, Andreas
Onur, Oezguer A.
Garcia Borrega, Jorge
Dimitriadis, Konstantinos
Günther, Albrecht
on behalf of the IGNITE Study Group
Sprache: Englisch
Titel: Journal of Clinical Medicine
Bandnummer: 11
Heft: 3
Verlag/Plattform: MDPI
Erscheinungsjahr: 2022
Freie Schlagwörter: COVID-19
intracranial hemorrhage
prognosis
anticoagulation
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) profoundly impacts hemostasis and microvasculature. In the light of the dilemma between thromboembolic and hemorrhagic complications, in the present paper, we systematically investigate the prevalence, mortality, radiological subtypes, and clinical characteristics of intracranial hemorrhage (ICH) in coronavirus disease (COVID-19) patients. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we performed a systematic review of the literature by screening the PubMed database and included patients diagnosed with COVID-19 and concomitant ICH. We performed a pooled analysis, including a prospectively collected cohort of critically ill COVID-19 patients with ICH, as part of the PANDEMIC registry (Pooled Analysis of Neurologic Disorders Manifesting in Intensive Care of COVID-19). Results: Our literature review revealed a total of 217 citations. After the selection process, 79 studies and a total of 477 patients were included. The median age was 58.8 years. A total of 23.3% of patients experienced the critical stage of COVID-19, 62.7% of patients were on anticoagulation and 27.5% of the patients received ECMO. The prevalence of ICH was at 0.85% and the mortality at 52.18%, respectively. Conclusion: ICH in COVID-19 patients is rare, but it has a very poor prognosis. Different subtypes of ICH seen in COVID-19, support the assumption of heterogeneous and multifaceted pathomechanisms contributing to ICH in COVID-19. Further clinical and pathophysiological investigations are warranted to resolve the conflict between thromboembolic and hemorrhagic complications in the future.
DOI der Erstveröffentlichung: 10.3390/jcm11030605
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-354786
hdl:20.500.11880/32413
http://dx.doi.org/10.22028/D291-35478
ISSN: 2077-0383
Erstgutachter: Attribution 4.0 International (CC BY 4.0)
Datum des Eintrags: 18-Feb-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Materials
In Beziehung stehendes Objekt: https://www.mdpi.com/article/10.3390/jcm11030605/s1
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Neurologie und Psychiatrie
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Dateien zu diesem Datensatz:
Datei Beschreibung GrößeFormat 
jcm-11-00605.pdf3,01 MBAdobe PDFÖffnen/Anzeigen


Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons