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doi:10.22028/D291-35471
Titel: | Primary Tumor Resection Decelerates Disease Progression in an Orthotopic Mouse Model of Metastatic Prostate Cancer |
VerfasserIn: | Linxweiler, Johannes Hajili, Turkan Zeuschner, Philip Menger, Michael D. Stöckle, Michael Junker, Kerstin Saar, Matthias |
Sprache: | Englisch |
Titel: | Cancers |
Bandnummer: | 14 |
Heft: | 3 |
Verlag/Plattform: | MDPI |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | cytoreductive primary tumor removal metastases orthotopic mouse model oligometastatic prostate cancer radical prostatectomy |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Radical prostatectomy in oligometastatic prostate cancer is a matter of intense debate. Besides avoiding local complications, it is hypothesized that primary tumor resection may result in better oncological outcomes. The aim of our study was to analyze the effect of primary tumor resection on disease progression in an orthotopic prostate cancer mouse model. First, the optimal time point for primary tumor resection, when metastases have already occurred, but the primary tumor is still resectable, was determined as 8 weeks after inoculation of 5 × 105 LuCaP136 cells. In a second in vivo experiment, 64 mice with metastatic prostate cancer were randomized into two groups, primary tumor resection or sham operation, and disease progression was followed up for 10 weeks. The technique of orthotopic primary tumor resection was successfully established. Compared with the sham operation group, mice with primary tumor resection showed a significantly longer survival (p < 0.001), a significantly slower PSA increase (p < 0.01), and a lower number of lung metastases (p = 0.073). In conclusion, primary tumor resection resulted in slower disease progression and longer survival in an orthotopic mouse model of metastatic prostate cancer. In future studies, this model will be used to unravel the molecular mechanisms of primary tumor/metastasis interaction in prostate cancer. |
DOI der Erstveröffentlichung: | 10.3390/cancers14030737 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-354719 hdl:20.500.11880/32403 http://dx.doi.org/10.22028/D291-35471 |
ISSN: | 2072-6694 |
Datum des Eintrags: | 17-Feb-2022 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Chirurgie M - Urologie und Kinderurologie |
Professur: | M - Prof. Dr. Michael D. Menger M - Prof. Dr. Michael Stöckle |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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cancers-14-00737.pdf | 3,47 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons