Please use this identifier to cite or link to this item: doi:10.22028/D291-35471
Title: Primary Tumor Resection Decelerates Disease Progression in an Orthotopic Mouse Model of Metastatic Prostate Cancer
Author(s): Linxweiler, Johannes
Hajili, Turkan
Zeuschner, Philip
Menger, Michael D.
Stöckle, Michael
Junker, Kerstin
Saar, Matthias
Language: English
Title: Cancers
Volume: 14
Issue: 3
Publisher/Platform: MDPI
Year of Publication: 2022
Free key words: cytoreductive primary tumor removal
orthotopic mouse model
oligometastatic prostate cancer
radical prostatectomy
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Radical prostatectomy in oligometastatic prostate cancer is a matter of intense debate. Besides avoiding local complications, it is hypothesized that primary tumor resection may result in better oncological outcomes. The aim of our study was to analyze the effect of primary tumor resection on disease progression in an orthotopic prostate cancer mouse model. First, the optimal time point for primary tumor resection, when metastases have already occurred, but the primary tumor is still resectable, was determined as 8 weeks after inoculation of 5 × 105 LuCaP136 cells. In a second in vivo experiment, 64 mice with metastatic prostate cancer were randomized into two groups, primary tumor resection or sham operation, and disease progression was followed up for 10 weeks. The technique of orthotopic primary tumor resection was successfully established. Compared with the sham operation group, mice with primary tumor resection showed a significantly longer survival (p < 0.001), a significantly slower PSA increase (p < 0.01), and a lower number of lung metastases (p = 0.073). In conclusion, primary tumor resection resulted in slower disease progression and longer survival in an orthotopic mouse model of metastatic prostate cancer. In future studies, this model will be used to unravel the molecular mechanisms of primary tumor/metastasis interaction in prostate cancer.
DOI of the first publication: 10.3390/cancers14030737
Link to this record: urn:nbn:de:bsz:291--ds-354719
ISSN: 2072-6694
Date of registration: 17-Feb-2022
Faculty: M - Medizinische Fakultät
Department: M - Chirurgie
M - Urologie und Kinderurologie
Professorship: M - Prof. Dr. Michael D. Menger
M - Prof. Dr. Michael Stöckle
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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