Please use this identifier to cite or link to this item:
doi:10.22028/D291-35178
Title: | Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex |
Author(s): | Schrecker, Jens Seitz, Berthold Berger, Tim Daas, Loay Behrens-Baumann, Wolfgang Auw-Hädrich, Claudia Schütt, Sabine Kerl, Sabine Rentner-Andres, Sascha Hof, Herbert |
Language: | English |
Title: | Journal of Fungi |
Volume: | 7 |
Issue: | 12 |
Publisher/Platform: | MDPI |
Year of Publication: | 2021 |
Free key words: | Fusarium solani ocular infection fungal keratitis keratoplasty antimycotics |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Fusarium spp. are moulds ubiquitously distributed in nature and only occasionally pathogenic for humans. Species of the Fusarium solani complex are the predominant keratitis inducing pathogens, because they are endowed with proper virulence factors. These fungi can adhere to the cornea creating a biofilm and, with the help of enzymes and cytotoxins, penetrate the cornea. Whereas an intact cornea is hardly able to be invaded by Fusarium spp. in spite of appropriate virulence factors, these opportunistic fungi may profit from predisposing conditions, for example mechanical injuries. This can lead to a progressive course of corneal infection and may finally affect the whole eye up to the need for enucleation. Here, we present and discuss the clinical, microbiological and histopathological aspects of a particular case due to Fusarium tonkinense of the Fusarium solani complex with severe consequences in a patient without any obvious predisposing factors. A broad portfolio of antifungal agents was applied, both topically and systemically as well as two penetrating keratoplasties were performed. The exact determination of the etiologic agent of the fungal infection proved likewise to be very challenging. |
DOI of the first publication: | 10.3390/jof7121093 |
Link to this record: | urn:nbn:de:bsz:291--ds-351781 hdl:20.500.11880/32160 http://dx.doi.org/10.22028/D291-35178 |
ISSN: | 2309-608X |
Date of registration: | 10-Jan-2022 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Augenheilkunde |
Professorship: | M - Prof. Dr. Berthold Seitz |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
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jof-07-01093-v2.pdf | 5,55 MB | Adobe PDF | View/Open |
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