Please use this identifier to cite or link to this item: doi:10.22028/D291-35178
Title: Malignant Keratitis Caused by a Highly-Resistant Strain of Fusarium Tonkinense from the Fusarium Solani Complex
Author(s): Schrecker, Jens
Seitz, Berthold
Berger, Tim
Daas, Loay
Behrens-Baumann, Wolfgang
Auw-Hädrich, Claudia
Schütt, Sabine
Kerl, Sabine
Rentner-Andres, Sascha
Hof, Herbert
Language: English
Title: Journal of Fungi
Volume: 7
Issue: 12
Publisher/Platform: MDPI
Year of Publication: 2021
Free key words: Fusarium solani
ocular infection
fungal keratitis
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Fusarium spp. are moulds ubiquitously distributed in nature and only occasionally pathogenic for humans. Species of the Fusarium solani complex are the predominant keratitis inducing pathogens, because they are endowed with proper virulence factors. These fungi can adhere to the cornea creating a biofilm and, with the help of enzymes and cytotoxins, penetrate the cornea. Whereas an intact cornea is hardly able to be invaded by Fusarium spp. in spite of appropriate virulence factors, these opportunistic fungi may profit from predisposing conditions, for example mechanical injuries. This can lead to a progressive course of corneal infection and may finally affect the whole eye up to the need for enucleation. Here, we present and discuss the clinical, microbiological and histopathological aspects of a particular case due to Fusarium tonkinense of the Fusarium solani complex with severe consequences in a patient without any obvious predisposing factors. A broad portfolio of antifungal agents was applied, both topically and systemically as well as two penetrating keratoplasties were performed. The exact determination of the etiologic agent of the fungal infection proved likewise to be very challenging.
DOI of the first publication: 10.3390/jof7121093
Link to this record: urn:nbn:de:bsz:291--ds-351781
ISSN: 2309-608X
Date of registration: 10-Jan-2022
Faculty: M - Medizinische Fakultät
Department: M - Augenheilkunde
Professorship: M - Prof. Dr. Berthold Seitz
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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