Please use this identifier to cite or link to this item:
doi:10.22028/D291-35044
Title: | Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells |
Author(s): | Redon, Christophe E. Schmal, Zoe Tewary, Gargi Mangelinck, Adèle Courbeyrette, Régis Thuret, Jean-Yves Aladjem, Mirit I. Bonner, William M. Rübe, Claudia E. Mann, Carl |
Language: | English |
Title: | Genes |
Volume: | 12 |
Issue: | 11 |
Publisher/Platform: | MDPI |
Year of Publication: | 2021 |
Free key words: | histone variant H2A.J luminal breast cancer luminal prostate cancer cancer biomarker H2AFJ H2AJ estrogen-responsive genes |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | H2A.J is a poorly studied mammalian-specific variant of histone H2A. We used immuno histochemistry to study its localization in various human and mouse tissues. H2A.J showed cell-type specific expression with a striking enrichment in luminal epithelial cells of multiple glands including those of breast, prostate, pancreas, thyroid, stomach, and salivary glands. H2A.J was also highly ex pressed in many carcinoma cell lines and in particular, those derived from luminal breast and prostate cancer. H2A.J thus appears to be a novel marker for luminal epithelial cancers. Knocking-out the H2AFJ gene in T47D luminal breast cancer cells reduced the expression of several estrogen-responsive genes which may explain its putative tumorigenic role in luminal-B breast cancer. |
DOI of the first publication: | 10.3390/genes12111665 |
Link to this record: | urn:nbn:de:bsz:291--ds-350440 hdl:20.500.11880/32053 http://dx.doi.org/10.22028/D291-35044 |
ISSN: | 2073-4425 |
Date of registration: | 16-Dec-2021 |
Description of the related object: | Supplementary Material |
Related object: | https://www.mdpi.com/2073-4425/12/11/1665/s1 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Radiologie |
Professorship: | M - Prof. Dr. Christian Rübe |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
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genes-12-01665-v4.pdf | 7,8 MB | Adobe PDF | View/Open |
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