Please use this identifier to cite or link to this item: doi:10.22028/D291-35044
Title: Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells
Author(s): Redon, Christophe E.
Schmal, Zoe
Tewary, Gargi
Mangelinck, Adèle
Courbeyrette, Régis
Thuret, Jean-Yves
Aladjem, Mirit I.
Bonner, William M.
Rübe, Claudia E.
Mann, Carl
Language: English
Title: Genes
Volume: 12
Issue: 11
Publisher/Platform: MDPI
Year of Publication: 2021
Free key words: histone variant H2A.J
luminal breast cancer
luminal prostate cancer
cancer biomarker
estrogen-responsive genes
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: H2A.J is a poorly studied mammalian-specific variant of histone H2A. We used immuno histochemistry to study its localization in various human and mouse tissues. H2A.J showed cell-type specific expression with a striking enrichment in luminal epithelial cells of multiple glands including those of breast, prostate, pancreas, thyroid, stomach, and salivary glands. H2A.J was also highly ex pressed in many carcinoma cell lines and in particular, those derived from luminal breast and prostate cancer. H2A.J thus appears to be a novel marker for luminal epithelial cancers. Knocking-out the H2AFJ gene in T47D luminal breast cancer cells reduced the expression of several estrogen-responsive genes which may explain its putative tumorigenic role in luminal-B breast cancer.
DOI of the first publication: 10.3390/genes12111665
Link to this record: urn:nbn:de:bsz:291--ds-350440
ISSN: 2073-4425
Date of registration: 16-Dec-2021
Description of the related object: Supplementary Material
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Radiologie
Professorship: M - Prof. Dr. Christian Rübe
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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