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Titel: HPV Status as Prognostic Biomarker in Head and Neck Cancer : Which Method Fits the Best for Outcome Prediction?
VerfasserIn: Kühn, Jan Philipp
Schmid, Wendelin
Körner, Sandrina
Bochen, Florian
Wemmert, Silke
Rimbach, Hugo
Smola, Sigrun
Radosa, Julia Caroline
Wagner, Mathias
Morris, Luc G.T.
Bozzato, Victoria
Bozzato, Alessandro
Schick, Bernhard
Linxweiler, Maximilian
Sprache: Englisch
Titel: Cancers
Bandnummer: 13
Heft: 18
Verlag/Plattform: MDPI
Erscheinungsjahr: 2021
Freie Schlagwörter: head and neck cancer
HPV
prognosis
biomarker
p16
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: The incidence of human papillomavirus (HPV)-related head and neck cancer (HNSCC) is rising globally, presenting challenges for optimized clinical management. To date, it remains unclear which biomarker best reflects HPV-driven carcinogenesis, a process that is associated with better therapeutic response and outcome compared to tobacco/alcohol-induced cancers. Six potential HPV surrogate biomarkers were analyzed using FFPE tissue samples from 153 HNSCC patients (n = 78 oropharyngeal cancer (OPSCC), n = 35 laryngeal cancer, n = 23 hypopharyngeal cancer, n = 17 oral cavity cancer): p16, CyclinD1, pRb, dual immunohistochemical staining of p16 and Ki67, HPV-DNA-PCR, and HPV-DNA-in situ hybridization (ISH). Biomarkers were analyzed for correlation with one another, tumor subsite, and patient survival. P16-IHC alone showed the best performance for discriminating between good (high expression) vs poor outcome (low expression; p = 0.0030) in OPSCC patients. Additionally, HPV-DNA-ISH (p = 0.0039), HPV-DNA-PCR (p = 0.0113), and p16-Ki67 dual stain (p = 0.0047) were significantly associated with prognosis in uniand multivariable analysis for oropharyngeal cancer. In the non-OPSCC group, however, none of the aforementioned surrogate markers was prognostic. Taken together, P16-IHC as a single biomarker displays the best diagnostic accuracy for prognosis stratification in OPSCC patients with a direct detection of HPV-DNA by PCR or ISH as well as p16-Ki67 dual stain as potential alternatives.
DOI der Erstveröffentlichung: 10.3390/cancers13184730
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-347653
hdl:20.500.11880/31838
http://dx.doi.org/10.22028/D291-34765
ISSN: 2072-6694
Datum des Eintrags: 12-Okt-2021
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Materials
In Beziehung stehendes Objekt: https://www.mdpi.com/article/10.3390/cancers13184730/s1
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Frauenheilkunde
M - Hals-Nasen-Ohrenheilkunde
M - Infektionsmedizin
M - Medizinische Biochemie und Molekularbiologie
M - Pathologie
Professur: M - Prof. Dr. Bernhard Schick
M - Prof. Dr. Sigrun Smola
M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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