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Titel: Increased B-cell activity with consumption of activated monocytes in severe COVID-19 patients
VerfasserIn: Kos, Igor
Balensiefer, Benedikt
Lesan, Vadim
Kaddu-Mulindwa, Dominic
Thurner, Lorenz
Christofyllakis, Konstantin
Bittenbring, Joerg Thomas
Ahlgrimm, Manfred
Seiffert, Martina
Wagenpfeil, Stefan
Bewarder, Yvonne
Neumann, Frank
Rixecker, Torben
Smola, Sigrun
Link, Andreas
Krawczyk, Marcin
Lammert, Frank
Lepper, Philipp M.
Bals, Robert
Stilgenbauer, Stephan
Bewarder, Moritz
Sprache: Englisch
Titel: European Journal of Immunology
Bandnummer: 51
Heft: 6
Seiten: 1449-1460
Verlag/Plattform: Wiley
Erscheinungsjahr: 2021
Freie Schlagwörter: Autoimmunity
B/T-cell ratio
COVID-19
Lymphocytes
Monocytes
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: The pathogenesis of autoimmune complications triggered by SARS-CoV2 has not been completely elucidated. Here, we performed an analysis of the cellular immune status, cell ratios, and monocyte populations of patients with COVID-19 treated in the intensive care unit (ICU) (cohort 1, N = 23) and normal care unit (NCU) (cohort 2, n = 10) compared with control groups: patients treated in ICU for noninfectious reasons (cohort 3, n = 30) and patients treated in NCU for infections other than COVID-19 (cohort 4, n = 21). Patients in cohort 1 presented significant differences in comparison with the other cohorts, including reduced frequencies of lymphocytes, reduced CD8+T-cell count, reduced percentage of activated and intermediate monocytes and an increased B/T8 cell ratio. Over time, patients in cohort 1 who died presented with lower counts of B, T, CD4+T, CD8+T-lymphocytes, NK cells, and activated monocytes. The B/T8 ratio was significantly lower in the group of survivors. In cohort 1, significantly higher levels of IgG1 and IgG3 were found, whereas cohort 3 presented higher levels of IgG3 compared to controls. Among many immune changes, an elevated B/T8-cell ratio and a reduced rate of activated monocytes were mainly observed in patients with severe COVID-19. Both parameters were associated with death in cohort 1.
DOI der Erstveröffentlichung: 10.1002/eji.202049163
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-346099
hdl:20.500.11880/31687
http://dx.doi.org/10.22028/D291-34609
ISSN: 1521-4141
0014-2980
Datum des Eintrags: 1-Sep-2021
Bezeichnung des in Beziehung stehenden Objekts: Supporting Information
In Beziehung stehendes Objekt: https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Feji.202049163&file=eji5038-sup-0001-SuppMat.pdf
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Infektionsmedizin
M - Innere Medizin
M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
Professur: M - Prof. Dr. Robert Bals
M - Prof. Dr. Frank Lammert
M - Prof. Dr. Sigrun Smola
M - Prof. Dr. Stephan Stilgenbauer
M - Prof. Dr. Stefan Wagenpfeil
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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