Please use this identifier to cite or link to this item: doi:10.22028/D291-34609
Title: Increased B-cell activity with consumption of activated monocytes in severe COVID-19 patients
Author(s): Kos, Igor
Balensiefer, Benedikt
Lesan, Vadim
Kaddu-Mulindwa, Dominic
Thurner, Lorenz
Christofyllakis, Konstantin
Bittenbring, Joerg Thomas
Ahlgrimm, Manfred
Seiffert, Martina
Wagenpfeil, Stefan
Bewarder, Yvonne
Neumann, Frank
Rixecker, Torben
Smola, Sigrun
Link, Andreas
Krawczyk, Marcin
Lammert, Frank
Lepper, Philipp M.
Bals, Robert
Stilgenbauer, Stephan
Bewarder, Moritz
Language: English
Title: European Journal of Immunology
Volume: 51
Issue: 6
Pages: 1449-1460
Publisher/Platform: Wiley
Year of Publication: 2021
Free key words: Autoimmunity
B/T-cell ratio
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: The pathogenesis of autoimmune complications triggered by SARS-CoV2 has not been completely elucidated. Here, we performed an analysis of the cellular immune status, cell ratios, and monocyte populations of patients with COVID-19 treated in the intensive care unit (ICU) (cohort 1, N = 23) and normal care unit (NCU) (cohort 2, n = 10) compared with control groups: patients treated in ICU for noninfectious reasons (cohort 3, n = 30) and patients treated in NCU for infections other than COVID-19 (cohort 4, n = 21). Patients in cohort 1 presented significant differences in comparison with the other cohorts, including reduced frequencies of lymphocytes, reduced CD8+T-cell count, reduced percentage of activated and intermediate monocytes and an increased B/T8 cell ratio. Over time, patients in cohort 1 who died presented with lower counts of B, T, CD4+T, CD8+T-lymphocytes, NK cells, and activated monocytes. The B/T8 ratio was significantly lower in the group of survivors. In cohort 1, significantly higher levels of IgG1 and IgG3 were found, whereas cohort 3 presented higher levels of IgG3 compared to controls. Among many immune changes, an elevated B/T8-cell ratio and a reduced rate of activated monocytes were mainly observed in patients with severe COVID-19. Both parameters were associated with death in cohort 1.
DOI of the first publication: 10.1002/eji.202049163
Link to this record: urn:nbn:de:bsz:291--ds-346099
ISSN: 1521-4141
Date of registration: 1-Sep-2021
Description of the related object: Supporting Information
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Infektionsmedizin
M - Innere Medizin
M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
Professorship: M - Prof. Dr. Robert Bals
M - Prof. Dr. Frank Lammert
M - Prof. Dr. Sigrun Smola
M - Prof. Dr. Stephan Stilgenbauer
M - Prof. Dr. Stefan Wagenpfeil
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Files for this record:
File Description SizeFormat 
eji.202049163.pdf1,79 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons