Please use this identifier to cite or link to this item:
doi:10.22028/D291-34608
Title: | Association between neuropathy and B-vitamins: A systematic review and meta-analysis |
Author(s): | Stein, Johannes Geisel, Juergen Obeid, Rima |
Language: | English |
Title: | European Journal of Neurology |
Volume: | 28 |
Issue: | 6 |
Pages: | 2054-2064 |
Publisher/Platform: | Wiley |
Year of Publication: | 2021 |
Free key words: | diabetes homocysteine peripheral neuropathy vitamin B1 vitamin B12 vitamin B6 vitamin deficiency |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Background Peripheral neuropathy (PN) is common in patients with diseases that are in turn associated with deficiency of the B-vitamins, and vitamin treatment has shown mixed results. Methods This systematic review and meta-analysis studied the association between PN/pain and B-vitamin biomarkers and investigated whether vitamin treatment can ameliorate the symptoms. PubMed and Web of Science were searched according to the study protocol. Results A total of 46 observational and seven interventional studies were identified and included in the data synthesis. The presence of PN was associated with lowered B12 levels (pooled estimate [95% CIs] = 1.51 [1.23–1.84], n = 34, Cochran Q Test I2 = 43.3%, p = 0.003) and elevated methylmalonic acid (2.53 [1.39–4.60], n = 9, I2 = 63.8%, p = 0.005) and homocysteine (3.48 [2.01–6.04], n = 15, I2 = 70.6%, p < 0.001). B12 treatment (vs. the comparators) showed a non-significant association with symptom improvement (1.36 (0.66–2.79), n = 4, I2 = 28.9%). Treatment with B1 was associated with a significant improvement in symptoms (5.34 [1.87–15.19], n = 3, I2 = 64.6%, p = 0.059). Analysis of seven trials combined showed a non-significant higher odds ratio for improvement under treatment with the B-vitamins (2.58 [0.98–6.79], I2 = 80.0%, p < 0.001). Conclusions PN is associated with lowered plasma vitamin B12 and elevated methylmalonic acid and homocysteine. Overall, interventional studies have suggested that B-vitamins could improve symptoms of PN. Available trials have limitations and generally did not investigate vitamin status prior to treatment. Well-designed studies, especially in non-diabetes PN, are needed. This meta-analysis is registered at PROSPERO (ID: CRD42020144917). |
DOI of the first publication: | 10.1111/ene.14786 |
Link to this record: | urn:nbn:de:bsz:291--ds-346084 hdl:20.500.11880/31684 http://dx.doi.org/10.22028/D291-34608 |
ISSN: | 1468-1331 1351-5101 |
Date of registration: | 1-Sep-2021 |
Description of the related object: | Supporting Information |
Related object: | https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fene.14786&file=ene14786-sup-0001-FigS1-S11.pptx https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fene.14786&file=ene14786-sup-0002-TableS1-S10.docx |
Faculty: | M - Medizinische Fakultät |
Department: | M - Innere Medizin |
Professorship: | M - Keiner Professur zugeordnet |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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