Please use this identifier to cite or link to this item:
doi:10.22028/D291-34595
Title: | Real-Time Evaluation of Optic Nerve Sheath Diameter (ONSD) in Awake, Spontaneously Breathing Patients |
Author(s): | Weidner, Nick Kretschmann, Jessica Bomberg, Hagen Antes, Sebastian Leonhardt, Steffen Tschan, Christoph Oertel, Joachim Volk, Thomas Meiser, Andreas Groesdonk, Heinrich V. |
Language: | English |
Title: | Journal of Clinical Medicine |
Volume: | 10 |
Issue: | 16 |
Publisher/Platform: | MDPI |
Year of Publication: | 2021 |
Free key words: | elevated intracranial pressure non-invasive ICP measurement ONSD |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | (1) Background: Reliable ultrasonographic measurements of optic nerve sheath diameter (ONSD) to detect increased intracerebral pressure (ICP) has not been established in awake patients with continuous invasive ICP monitoring. Therefore, in this study, we included fully awake patients with and without raised ICP and correlated ONSD with continuously measured ICP values. (2) Methods: In a prospective study, intracranial pressure (ICP) was continuously measured in 25 patients with an intraparenchymatic P-tel probe. Ultrasonic measurements were carried out three times for each optic nerve in vertical and horizontal directions. ONSD measurements and ICP were correlated. Patients with ICP of 2.0–10.0 mmHg were compared with patients suffering from an ICP of 10.1–24.2 mmHg. (3) Results: In all patients, the ONSD vertical and horizontal measurement for both eyes correlated well with the ICP (Pearson R = 0.68–0.80). Both measurements yielded similar results (Bland-Altman: vertical bias: −0.09 mm, accuracy: ±0.66 mm; horizontal bias: −0.06 mm, accuracy: ±0.48 mm). For patients with an ICP of 2.0–10.0 mmHg compared to an ICP of 10.1–24.2, ROC (receiver operating characteristic) analyses showed that ONSD measurement accurately predicts elevated ICP (optimal cut-off value 5.05 mm, AUC of 0.91, sensitivity 92% and specificity 90%, p < 0.001). (4) Conclusions: Ultrasonographic measurement of ONSD in awake, spontaneously breathing patients provides a valuable method to evaluate patients with suspected increased ICP. Additionally, it provides a potential tool for rapid assessment of ICP at the bedside and to identify patients at risk for a poor neurological outcome. |
DOI of the first publication: | 10.3390/jcm10163549 |
Link to this record: | urn:nbn:de:bsz:291--ds-345953 hdl:20.500.11880/31668 http://dx.doi.org/10.22028/D291-34595 |
ISSN: | 2077-0383 |
Date of registration: | 30-Aug-2021 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Anästhesiologie M - Neurochirurgie |
Professorship: | M - Prof. Dr. Joachim Oertel M - Prof. Dr. Thomas Volk |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
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jcm-10-03549-v2.pdf | 3,56 MB | Adobe PDF | View/Open |
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