Please use this identifier to cite or link to this item:
doi:10.22028/D291-34212
Title: | Oligodendroglial GABAergic Signaling: More Than Inhibition! |
Author(s): | Bai, Xianshu Kirchhoff, Frank Scheller, Anja |
Language: | English |
Title: | Neuroscience Bulletin |
Publisher/Platform: | Springer Nature |
Year of Publication: | 2021 |
Free key words: | GABA GABAA receptor GABAB receptor OPC Oligodendrocyte lineage |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | GABA is the main inhibitory neurotransmitter in the CNS acting at two distinct types of receptor: ligand-gated ionotropic GABAA receptors and G protein-coupled metabotropic GABAB receptors, thus mediating fast and slow inhibition of excitability at central synapses. GABAergic signal transmission has been intensively studied in neurons in contrast to oligodendrocytes and their precursors (OPCs), although the latter express both types of GABA receptor. Recent studies focusing on interneuron myelination and interneuron-OPC synapses have shed light on the importance of GABA signaling in the oligodendrocyte lineage. In this review, we start with a short summary on GABA itself and neuronal GABAergic signaling. Then, we elaborate on the physiological role of GABA receptors within the oligodendrocyte lineage and conclude with a description of these receptors as putative targets in treatments of CNS diseases. |
DOI of the first publication: | 10.1007/s12264-021-00693-w |
Link to this record: | urn:nbn:de:bsz:291--ds-342120 hdl:20.500.11880/31398 http://dx.doi.org/10.22028/D291-34212 |
ISSN: | 1995-8218 1673-7067 |
Date of registration: | 21-Jun-2021 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Physiologie |
Professorship: | M - Prof. Dr. Frank Kirchhoff |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
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Bai2021_Article_OligodendroglialGABAergicSigna.pdf | 5,69 MB | Adobe PDF | View/Open |
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