Please use this identifier to cite or link to this item: doi:10.22028/D291-34212
Title: Oligodendroglial GABAergic Signaling: More Than Inhibition!
Author(s): Bai, Xianshu
Kirchhoff, Frank
Scheller, Anja
Language: English
Title: Neuroscience Bulletin
Publisher/Platform: Springer Nature
Year of Publication: 2021
Free key words: GABA
GABAA receptor
GABAB receptor
Oligodendrocyte lineage
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: GABA is the main inhibitory neurotransmitter in the CNS acting at two distinct types of receptor: ligand-gated ionotropic GABAA receptors and G protein-coupled metabotropic GABAB receptors, thus mediating fast and slow inhibition of excitability at central synapses. GABAergic signal transmission has been intensively studied in neurons in contrast to oligodendrocytes and their precursors (OPCs), although the latter express both types of GABA receptor. Recent studies focusing on interneuron myelination and interneuron-OPC synapses have shed light on the importance of GABA signaling in the oligodendrocyte lineage. In this review, we start with a short summary on GABA itself and neuronal GABAergic signaling. Then, we elaborate on the physiological role of GABA receptors within the oligodendrocyte lineage and conclude with a description of these receptors as putative targets in treatments of CNS diseases.
DOI of the first publication: 10.1007/s12264-021-00693-w
Link to this record: urn:nbn:de:bsz:291--ds-342120
ISSN: 1995-8218
Date of registration: 21-Jun-2021
Faculty: M - Medizinische Fakultät
Department: M - Physiologie
Professorship: M - Prof. Dr. Frank Kirchhoff
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Files for this record:
File Description SizeFormat 
Bai2021_Article_OligodendroglialGABAergicSigna.pdf5,69 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons