Please use this identifier to cite or link to this item:
doi:10.22028/D291-33196
Title: | Pitfalls in drug testing by hyphenated low- and high-resolution mass spectrometry |
Author(s): | Maurer, Hans H. |
Language: | English |
Title: | Drug Testing and Analysis |
Volume: | 12 |
Issue: | 2 |
Pages: | 172–179 |
Publisher/Platform: | Wiley |
Year of Publication: | 2019 |
Free key words: | Drug testing Mass spectrometry Pitfall Screening |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | This paper reviews various pitfalls observed during developing, validation, application, and interpretation of drug testing approaches using GC-MS and low- and high-resolution LC-MS. They include sampling and storage of body samples, sample adulteration and contamination, analyte stability, sample preparation without or with cleavage of conjugates, extraction, derivatization, internal standardization, false negative and positive results by GC-MS or LC-MS screening and/or confirmation procedures including artifact formation, ion suppression or enhancement by electrospray ionization, and finally pitfalls in data interpretation. Conclusions and prospects close the Tutorial. |
DOI of the first publication: | 10.1002/dta.2744 |
Link to this record: | urn:nbn:de:bsz:291--ds-331967 hdl:20.500.11880/30540 http://dx.doi.org/10.22028/D291-33196 |
ISSN: | 1942-7611 1942-7603 |
Date of registration: | 3-Feb-2021 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Experimentelle und Klinische Pharmakologie und Toxikologie |
Professorship: | M - Keiner Professur zugeordnet |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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dta.2744.pdf | 551,36 kB | Adobe PDF | View/Open |
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