Please use this identifier to cite or link to this item: doi:10.22028/D291-33196
Title: Pitfalls in drug testing by hyphenated low- and high-resolution mass spectrometry
Author(s): Maurer, Hans H.
Language: English
Title: Drug Testing and Analysis
Volume: 12
Issue: 2
Pages: 172–179
Publisher/Platform: Wiley
Year of Publication: 2019
Free key words: Drug testing
Mass spectrometry
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: This paper reviews various pitfalls observed during developing, validation, application, and interpretation of drug testing approaches using GC-MS and low- and high-resolution LC-MS. They include sampling and storage of body samples, sample adulteration and contamination, analyte stability, sample preparation without or with cleavage of conjugates, extraction, derivatization, internal standardization, false negative and positive results by GC-MS or LC-MS screening and/or confirmation procedures including artifact formation, ion suppression or enhancement by electrospray ionization, and finally pitfalls in data interpretation. Conclusions and prospects close the Tutorial.
DOI of the first publication: 10.1002/dta.2744
Link to this record: urn:nbn:de:bsz:291--ds-331967
ISSN: 1942-7611
Date of registration: 3-Feb-2021
Faculty: M - Medizinische Fakultät
Department: M - Experimentelle und Klinische Pharmakologie und Toxikologie
Professorship: M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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