Please use this identifier to cite or link to this item:
doi:10.22028/D291-30809
Title: | Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review |
Author(s): | Maretzke, Friederike Bechthold, Angela Egert, Sarah Ernst, Jana B. Melo van Lent, Debora Pilz, Stefan Reichrath, Jörg Stangl, Gabriele I. Stehle, Peter Volkert, Dorothee Wagner, Michael Waizenegger, Julia Zittermann, Armin Linseisen, Jakob |
Language: | English |
Title: | Nutrients |
Volume: | 12 |
Issue: | 4 |
Publisher/Platform: | MDPI |
Year of Publication: | 2020 |
Free key words: | vitamin D 25-hydroxyvitamin D (25(OH)D) asthma COPD ARI dementia and cognitive decline depression multiple sclerosis T1DM umbrella review |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Evidence is accumulating that vitamin D may have beneficial effects on respiratory tract, autoimmune, neuro-degenerative, and mental diseases. The present umbrella review of systematic reviews (SRs) of cohort studies and randomised controlled trials (RCTs), plus single Mendelian randomisation studies aims to update current knowledge on the potential role of vitamin D in preventing and treating these extraskeletal diseases. Altogether, 73 SRs were identified. Observational data on primary prevention suggest an inverse association between vitamin D status and the risk of acute respiratory tract infections (ARI), dementia and cognitive decline, and depression, whereas studies regarding asthma, multiple sclerosis (MS), and type 1 diabetes mellitus (T1DM) are scarce. SRs of RCTs support observational data only for the risk of ARI. No respective RCTs are available for the prevention of chronic obstructive pulmonary disease (COPD), MS, and T1DM. SRs of RCTs indicate beneficial therapeutic effects in vitamin D-deficient patients with asthma and COPD, while effects on major depression and T1DM need to be further elucidated. Mendelian randomisation studies do not consistently support the results of SRs. Since several limitations of the included SRs and existing RCTs do not permit definitive conclusions regarding vitamin D and the selected diseases, further high-quality RCTs are warranted. |
DOI of the first publication: | 10.3390/nu12040969 |
Link to this record: | urn:nbn:de:bsz:291--ds-308099 hdl:20.500.11880/30230 http://dx.doi.org/10.22028/D291-30809 |
ISSN: | 2072-6643 |
Date of registration: | 17-Dec-2020 |
Description of the related object: | Supplementary Materials |
Related object: | http://www.mdpi.com/2072-6643/12/4/969/s1 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Dermatologie |
Professorship: | M - Keiner Professur zugeordnet |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
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nutrients-12-00969-v2.pdf | 705,39 kB | Adobe PDF | View/Open |
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