Please use this identifier to cite or link to this item: doi:10.22028/D291-30809
Title: Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases—An Umbrella Review
Author(s): Maretzke, Friederike
Bechthold, Angela
Egert, Sarah
Ernst, Jana B.
Melo van Lent, Debora
Pilz, Stefan
Reichrath, Jörg
Stangl, Gabriele I.
Stehle, Peter
Volkert, Dorothee
Wagner, Michael
Waizenegger, Julia
Zittermann, Armin
Linseisen, Jakob
Language: English
Title: Nutrients
Volume: 12
Issue: 4
Publisher/Platform: MDPI
Year of Publication: 2020
Free key words: vitamin D
25-hydroxyvitamin D (25(OH)D)
dementia and cognitive decline
multiple sclerosis
umbrella review
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Evidence is accumulating that vitamin D may have beneficial effects on respiratory tract, autoimmune, neuro-degenerative, and mental diseases. The present umbrella review of systematic reviews (SRs) of cohort studies and randomised controlled trials (RCTs), plus single Mendelian randomisation studies aims to update current knowledge on the potential role of vitamin D in preventing and treating these extraskeletal diseases. Altogether, 73 SRs were identified. Observational data on primary prevention suggest an inverse association between vitamin D status and the risk of acute respiratory tract infections (ARI), dementia and cognitive decline, and depression, whereas studies regarding asthma, multiple sclerosis (MS), and type 1 diabetes mellitus (T1DM) are scarce. SRs of RCTs support observational data only for the risk of ARI. No respective RCTs are available for the prevention of chronic obstructive pulmonary disease (COPD), MS, and T1DM. SRs of RCTs indicate beneficial therapeutic effects in vitamin D-deficient patients with asthma and COPD, while effects on major depression and T1DM need to be further elucidated. Mendelian randomisation studies do not consistently support the results of SRs. Since several limitations of the included SRs and existing RCTs do not permit definitive conclusions regarding vitamin D and the selected diseases, further high-quality RCTs are warranted.
DOI of the first publication: 10.3390/nu12040969
Link to this record: urn:nbn:de:bsz:291--ds-308099
ISSN: 2072-6643
Date of registration: 17-Dec-2020
Description of the related object: Supplementary Materials
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Dermatologie
Professorship: M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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