Please use this identifier to cite or link to this item:
doi:10.22028/D291-30562
Title: | Lactobacillus Acidophilus/Bifidobacterium Infantis Probiotics Are Beneficial to Extremely Low Gestational Age Infants Fed Human Milk |
Author(s): | Fortmann, Ingmar Marißen, Janina Siller, Bastian Spiegler, Juliane Humberg, Alexander Hanke, Kathrin Faust, Kirstin Pagel, Julia Eyvazzadeh, Leila Brenner, Kim Roll, Claudia Pirr, Sabine Viemann, Dorothee Stavropoulou, Dimitra Henneke, Philipp Tröger, Birte Körner, Thorsten Stein, Anja Derouet, Christoph Zemlin, Michael Wieg, Christian Rupp, Jan Herting, Egbert Göpel, Wolfgang Härtel, Christoph |
Language: | English |
Title: | Nutrients |
Volume: | 12 |
Issue: | 3 |
Publisher/Platform: | MDPI |
Year of Publication: | 2020 |
Free key words: | probiotic prophylaxis human milk prematurity sepsis growth failure |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | To evaluate the nutrition-related effects of prophylactic Lactobacillus acidophilus/ Bifidobacterium infantis probiotics on the outcomes of preterm infants <29 weeks of gestation that receive human milk and/or formula nutrition. We hypothesize that human-milk-fed infants benefit from probiotics in terms of sepsis prevention and growth. Methods: We performed an observational study of the German Neonatal Network (GNN) over a period of six years, between 1 January, 2013 and 31 December, 2018. Prophylactic probiotic use of L. acidophilus/B. infantis was evaluated in preterm infants <29 weeks of gestation (n = 7516) in subgroups stratified to feeding type: (I) Exclusively human milk (HM) of own mother and/or donors (HM group, n = 1568), (II) HM of own mother and/or donor and formula (Mix group, n = 5221), and (III) exclusive exposure to formula (F group, n = 727). The effect of probiotics on general outcomes and growth was tested in univariate models and adjusted in linear/logistic regression models. Results: 5954 (76.5%) infants received L. acidophilus/B. infantisprophylactically for the prevention of necrotizing enterocolitis (NEC). Probiotic use was associated with improved growth measures in the HM group (e.g., weight gain velocity in g/day: effect size B = 0.224; 95% CI: 2.82–4.35; p < 0.001) but not in the F group (effect size B = −0.06; 95% CI: −3.05–0.28; p = 0.103). The HM group had the lowest incidence of clinical sepsis (34.0%) as compared to the Mix group (35.5%) and the F group (40.0%). Only in the Mix group, probiotic supplementation proved to be protective against clinical sepsis (OR 0.69; 95% CI: 0.59–0.79; p < 0.001). Conclusion: Our observational data indicate that the exposure to L. acidophilus/B. infantis probiotics may promote growth in exclusively HM-fed infants as compared to formula-fed infants. To exert a sepsis-preventive effect, probiotics seem to require human milk. |
DOI of the first publication: | 10.3390/nu12030850 |
Link to this record: | urn:nbn:de:bsz:291--ds-305625 hdl:20.500.11880/30209 http://dx.doi.org/10.22028/D291-30562 |
ISSN: | 2072-6643 |
Date of registration: | 15-Dec-2020 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Pädiatrie |
Professorship: | M - Prof. Dr. Michael Zemlin |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
---|---|---|---|---|
nutrients-12-00850.pdf | 446,67 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License