Please use this identifier to cite or link to this item: doi:10.22028/D291-30562
Title: Lactobacillus Acidophilus/Bifidobacterium Infantis Probiotics Are Beneficial to Extremely Low Gestational Age Infants Fed Human Milk
Author(s): Fortmann, Ingmar
Marißen, Janina
Siller, Bastian
Spiegler, Juliane
Humberg, Alexander
Hanke, Kathrin
Faust, Kirstin
Pagel, Julia
Eyvazzadeh, Leila
Brenner, Kim
Roll, Claudia
Pirr, Sabine
Viemann, Dorothee
Stavropoulou, Dimitra
Henneke, Philipp
Tröger, Birte
Körner, Thorsten
Stein, Anja
Derouet, Christoph
Zemlin, Michael
Wieg, Christian
Rupp, Jan
Herting, Egbert
Göpel, Wolfgang
Härtel, Christoph
Language: English
Title: Nutrients
Volume: 12
Issue: 3
Publisher/Platform: MDPI
Year of Publication: 2020
Free key words: probiotic prophylaxis
human milk
growth failure
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: To evaluate the nutrition-related effects of prophylactic Lactobacillus acidophilus/ Bifidobacterium infantis probiotics on the outcomes of preterm infants <29 weeks of gestation that receive human milk and/or formula nutrition. We hypothesize that human-milk-fed infants benefit from probiotics in terms of sepsis prevention and growth. Methods: We performed an observational study of the German Neonatal Network (GNN) over a period of six years, between 1 January, 2013 and 31 December, 2018. Prophylactic probiotic use of L. acidophilus/B. infantis was evaluated in preterm infants <29 weeks of gestation (n = 7516) in subgroups stratified to feeding type: (I) Exclusively human milk (HM) of own mother and/or donors (HM group, n = 1568), (II) HM of own mother and/or donor and formula (Mix group, n = 5221), and (III) exclusive exposure to formula (F group, n = 727). The effect of probiotics on general outcomes and growth was tested in univariate models and adjusted in linear/logistic regression models. Results: 5954 (76.5%) infants received L. acidophilus/B. infantisprophylactically for the prevention of necrotizing enterocolitis (NEC). Probiotic use was associated with improved growth measures in the HM group (e.g., weight gain velocity in g/day: effect size B = 0.224; 95% CI: 2.82–4.35; p < 0.001) but not in the F group (effect size B = −0.06; 95% CI: −3.05–0.28; p = 0.103). The HM group had the lowest incidence of clinical sepsis (34.0%) as compared to the Mix group (35.5%) and the F group (40.0%). Only in the Mix group, probiotic supplementation proved to be protective against clinical sepsis (OR 0.69; 95% CI: 0.59–0.79; p < 0.001). Conclusion: Our observational data indicate that the exposure to L. acidophilus/B. infantis probiotics may promote growth in exclusively HM-fed infants as compared to formula-fed infants. To exert a sepsis-preventive effect, probiotics seem to require human milk.
DOI of the first publication: 10.3390/nu12030850
Link to this record: urn:nbn:de:bsz:291--ds-305625
ISSN: 2072-6643
Date of registration: 15-Dec-2020
Faculty: M - Medizinische Fakultät
Department: M - Pädiatrie
Professorship: M - Prof. Dr. Michael Zemlin
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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