Please use this identifier to cite or link to this item:
doi:10.22028/D291-27870
Title: | Multi-Sensor Arrays for Online Monitoring of Cell Dynamics in in vitro Studies with Choroid Plexus Epithelial Cells |
Author(s): | Mestres-Ventura, Pedro Morguet, Andrea Gómez de las Heras, Soledad García |
Language: | English |
Title: | Sensors |
Volume: | 12 |
Issue: | 2 |
Startpage: | 1383 |
Endpage: | 1397 |
Publisher/Platform: | MDPI |
Year of Publication: | 2012 |
Free key words: | sensor arrays peri-cellular acidosis cell respiration cell adhesion impedance cell cultures electron microscopy choroid plexus chick embryo |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Sensors and multi-sensor arrays are the basis of new technologies for the non-label monitoring of cell activity. In this paper we show that choroid plexus cells can be cultured on silicon chips and that sensors register in real time changes in their activity, constituting an interesting experimental paradigm for cell biology and medical research. To validate the signals recorded (metabolism = peri-cellular acidification, oxygen consumption = respiration; impedance = adhesion, cell shape and motility) we performed experiments with compounds that act in a well-known way on cells, influencing these parameters. Our in vitro model demonstrates the advantages of multi-sensor arrays in assessment and experimental characterization of dynamic cellular events—in this case in choroid plexus functions, however with applicability to other cell types as well. |
DOI of the first publication: | 10.3390/s120201383 |
Link to this record: | urn:nbn:de:bsz:291--ds-278705 hdl:20.500.11880/29970 http://dx.doi.org/10.22028/D291-27870 |
ISSN: | 1424-8220 |
Date of registration: | 6-Nov-2020 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Anatomie und Zellbiologie |
Professorship: | M - Keiner Professur zugeordnet |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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sensors-12-01383-v2.pdf | 1,07 MB | Adobe PDF | View/Open |
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