Please use this identifier to cite or link to this item: doi:10.22028/D291-27870
Title: Multi-Sensor Arrays for Online Monitoring of Cell Dynamics in in vitro Studies with Choroid Plexus Epithelial Cells
Author(s): Mestres-Ventura, Pedro
Morguet, Andrea
Gómez de las Heras, Soledad García
Language: English
Title: Sensors
Volume: 12
Issue: 2
Startpage: 1383
Endpage: 1397
Publisher/Platform: MDPI
Year of Publication: 2012
Free key words: sensor arrays
peri-cellular acidosis
cell respiration
cell adhesion
cell cultures
electron microscopy
choroid plexus
chick embryo
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Sensors and multi-sensor arrays are the basis of new technologies for the non-label monitoring of cell activity. In this paper we show that choroid plexus cells can be cultured on silicon chips and that sensors register in real time changes in their activity, constituting an interesting experimental paradigm for cell biology and medical research. To validate the signals recorded (metabolism = peri-cellular acidification, oxygen consumption = respiration; impedance = adhesion, cell shape and motility) we performed experiments with compounds that act in a well-known way on cells, influencing these parameters. Our in vitro model demonstrates the advantages of multi-sensor arrays in assessment and experimental characterization of dynamic cellular events—in this case in choroid plexus functions, however with applicability to other cell types as well.
DOI of the first publication: 10.3390/s120201383
Link to this record: urn:nbn:de:bsz:291--ds-278705
ISSN: 1424-8220
Date of registration: 6-Nov-2020
Faculty: M - Medizinische Fakultät
Department: M - Anatomie und Zellbiologie
Professorship: M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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