Please use this identifier to cite or link to this item:
doi:10.22028/D291-27768
Title: | Acute Myeloid Leukemia Affects Mouse Sperm Parameters, Spontaneous Acrosome Reaction, and Fertility Capacity |
Author(s): | Michailov, Yulia Lunenfeld, Eitan Kapilushnik, Joseph Friedler, Shevach Meese, Eckart Huleihel, Mahmoud |
Language: | English |
Title: | International Journal of Molecular Sciences |
Volume: | 20 |
Issue: | 1 |
Publisher/Platform: | MDPI |
Year of Publication: | 2019 |
Free key words: | acute myeloid leukemia male infertility sperm parameters testis acrosome reaction |
DDC notations: | 570 Life sciences, biology 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Leukemia is one of the most common cancers in patients of reproductive age. It is well known that chemotherapy, used as anti-cancer therapy, adversely affects male fertility. Moreover, the negative effect of leukemia on sperm quality, even before chemotherapy treatment, has been reported. However, the mechanisms behind this disease’s effect on sperm quality remains unknown. In this study, we examine the direct effect of leukemia and chemotherapy alone and in combination on sperm parameters and male fertility. For this, we developed an acute myeloid leukemia (AML) mouse model (mice were treated with AML cells C1498 and developed leukemia); these mice then received cytarabine chemotherapy. Our findings reveal a significant reduction in sperm concentration and motility and a significant increase in abnormal morphology and spontaneous acrosome reaction of the sperm following AML and chemotherapy treatment, alone and in combination. We also found a reduction in male fertility and the number of delivered offspring. Our results support previous findings that AML impairs sperm parameters and show for the first time that AML increases spontaneous acrosome reaction and decreases male fertility capacity and number of offspring. |
DOI of the first publication: | 10.3390/ijms20010219 |
Link to this record: | urn:nbn:de:bsz:291--ds-277682 hdl:20.500.11880/29948 http://dx.doi.org/10.22028/D291-27768 |
ISSN: | 1422-0067 |
Date of registration: | 4-Nov-2020 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Humangenetik |
Professorship: | M - Prof. Dr. Eckhart Meese |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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File | Description | Size | Format | |
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ijms-20-00219.pdf | 2,14 MB | Adobe PDF | View/Open |
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