Please use this identifier to cite or link to this item: doi:10.22028/D291-27768
Title: Acute Myeloid Leukemia Affects Mouse Sperm Parameters, Spontaneous Acrosome Reaction, and Fertility Capacity
Author(s): Michailov, Yulia
Lunenfeld, Eitan
Kapilushnik, Joseph
Friedler, Shevach
Meese, Eckart
Huleihel, Mahmoud
Language: English
Title: International Journal of Molecular Sciences
Volume: 20
Issue: 1
Publisher/Platform: MDPI
Year of Publication: 2019
Free key words: acute myeloid leukemia
male infertility
sperm parameters
acrosome reaction
DDC notations: 570 Life sciences, biology
610 Medicine and health
Publikation type: Journal Article
Abstract: Leukemia is one of the most common cancers in patients of reproductive age. It is well known that chemotherapy, used as anti-cancer therapy, adversely affects male fertility. Moreover, the negative effect of leukemia on sperm quality, even before chemotherapy treatment, has been reported. However, the mechanisms behind this disease’s effect on sperm quality remains unknown. In this study, we examine the direct effect of leukemia and chemotherapy alone and in combination on sperm parameters and male fertility. For this, we developed an acute myeloid leukemia (AML) mouse model (mice were treated with AML cells C1498 and developed leukemia); these mice then received cytarabine chemotherapy. Our findings reveal a significant reduction in sperm concentration and motility and a significant increase in abnormal morphology and spontaneous acrosome reaction of the sperm following AML and chemotherapy treatment, alone and in combination. We also found a reduction in male fertility and the number of delivered offspring. Our results support previous findings that AML impairs sperm parameters and show for the first time that AML increases spontaneous acrosome reaction and decreases male fertility capacity and number of offspring.
DOI of the first publication: 10.3390/ijms20010219
Link to this record: urn:nbn:de:bsz:291--ds-277682
ISSN: 1422-0067
Date of registration: 4-Nov-2020
Faculty: M - Medizinische Fakultät
Department: M - Humangenetik
Professorship: M - Prof. Dr. Eckhart Meese
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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