Please use this identifier to cite or link to this item: doi:10.22028/D291-27883
Title: Supramolecular Cyclodextrin-Based Hydrogels for Controlled Gene Delivery
Author(s): Rey-Rico, Ana
Cucchiarini, Magali
Language: English
Title: Polymers
Volume: 11 (2019)
Issue: 3
Publisher/Platform: MDPI
Year of Publication: 2019
Free key words: supramolecular hydrogels
cyclodextrin-based polypseudorotaxane hydrogels
controlled gene delivery
nonviral vectors
viral vectors
gene transfer
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Controlled delivery of gene transfer vectors is a powerful strategy to enhance the temporal and spatial presentation of therapeutic agents in a defined target. Hydrogels are adapted biomaterials for gene delivery capable of acting as a localized depot of genes while maintaining the long term local availability of DNA vectors at a specific location. Supramolecular hydrogels based on cyclodextrins (CDs) have attracted considerable attention as potential biomaterials in a broad range of drug delivery applications. Their unique characteristics of thixotropicity and low cytotoxicity due to their production under mild conditions make them potential candidates to form injectable delivery systems. This work aims to provide an overview of the use of CD-based polypseudorotaxane hydrogels as controlled gene delivery systems for different applications in regenerative medicine.
DOI of the first publication: 10.3390/polym11030514
Link to this record: urn:nbn:de:bsz:291--ds-278830
ISSN: 2073-4360
Date of registration: 6-Oct-2020
Faculty: M - Medizinische Fakultät
Department: M - Orthopädie
Professorship: M - Prof. Dr. Henning Madry
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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