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doi:10.22028/D291-31944
Title: | Near-infrared-light regulated angiogenesis in a 4D hydrogel |
Author(s): | Zheng, Yijun Chen, Zhijun Jiang, Qiyang Feng, Jun Wu, Si del Campo Bécares, Aránzazu |
Language: | English |
Title: | Nanoscale |
Volume: | 12 |
Issue: | 25 |
Startpage: | 13654 |
Endpage: | 13661 |
Publisher/Platform: | RSC |
Year of Publication: | 2020 |
Publikation type: | Journal Article |
Abstract: | Light-responsive hydrogels are useful platforms to study cellular responses. Current photosensitive motifs need UV light to be activated, which is intrinsically cytotoxic and has a low penetration depth in tissues. Herein we describe a strategy for near-infrared (NIR) controlled activation of cellular processes (3D cell spreading and angiogenesis) by embedding upconverting nanoparticles (UCNPs) in a hydrogel modified with light-activatable cell adhesive motifs. The UCNPs can convert NIR light (974 nm) into local UV emission and activate photochemical reactions on-demand. Such optoregulation is spatially controllable, dose-dependent and can be performed at different timepoints of the cell culture without appreciable photodamage of the cells. HUVEC cells embedded in this hydrogel can form vascular networks at predefined geometries determined by the irradiation pattern. The penetration depth of NIR light enabled activation of the angiogenesis response through skin tissue with a thickness of 2.5 mm. Our strategy opens a new avenue for 4D cell cultures, with the potential to be extended to dynamically manipulate cell-matrix interactions and derived cellular processes in vivo. |
DOI of the first publication: | 10.1039/d0nr02552f |
URL of the first publication: | https://pubs.rsc.org/en/content/articlelanding/2020/nr/d0nr02552f#!divAbstract |
Link to this record: | hdl:20.500.11880/29592 http://dx.doi.org/10.22028/D291-31944 |
ISSN: | 2040-3372 2040-3364 |
Date of registration: | 27-Aug-2020 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Chemie |
Professorship: | NT - Prof. Dr. Aránzazu del Campo |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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