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doi:10.22028/D291-31066
Title: | A Stochastic Automata Network Description for Spatial DNA-Methylation Models |
Author(s): | Lück, Alexander Wolf, Verena |
Editor(s): | Hermanns, Holger |
Language: | English |
Title: | Measurement, Modelling and Evaluation of Computing Systems : 20th International GI/ITG Conference |
Startpage: | 54 |
Endpage: | 64 |
Publisher/Platform: | Springer |
Year of Publication: | 2020 |
Place of publication: | Cham |
Title of the Conference: | MMB 2020 |
Place of the conference: | Saarbrücken, Germany |
Publikation type: | Conference Paper |
Abstract: | DNA methylation is an important biological mechanism to regulate gene expression and control cell development. Mechanistic modeling has become a popular approach to enhance our understanding of the dynamics of methylation pattern formation in living cells. Recent findings suggest that the methylation state of a cytosine base can be influenced by its DNA neighborhood. Therefore, it is necessary to generalize existing mathematical models that consider only one cytosine and its partner on the opposite DNA-strand (CpG), in order to include such neighborhood dependencies. One approach is to describe the system as a stochastic automata network (SAN) with functional transitions. We show that single-CpG models can successfully be generalized to multiple CpGs using the SAN description and verify the results by comparing them to results from extensive Monte-Carlo simulations. |
DOI of the first publication: | 10.1007/978-3-030-43024-5_4 |
URL of the first publication: | https://link.springer.com/chapter/10.1007/978-3-030-43024-5_4 |
Link to this record: | hdl:20.500.11880/29207 http://dx.doi.org/10.22028/D291-31066 |
ISBN: | 978-3-030-43024-5 978-3-030-43023-8 |
Date of registration: | 29-May-2020 |
Notes: | Programming and Software Engineering ; volume 12040 |
Faculty: | MI - Fakultät für Mathematik und Informatik |
Department: | MI - Informatik |
Professorship: | MI - Prof. Dr. Verena Wolf |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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