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doi:10.22028/D291-30946
Title: | Delivery system for budesonide based on lipid-DNA |
Author(s): | Liu, Yun Bos, I. Sophie T. Oenema, Tjitske A. Meurs, Herman Maarsingh, Harm Hirsch, Anna |
Language: | English |
Title: | European journal of pharmaceutics and biopharmaceutics : EJPB |
Volume: | 130 |
Startpage: | 123 |
Endpage: | 127 |
Publisher/Platform: | Elsevier |
Year of Publication: | 2018 |
Publikation type: | Journal Article |
Abstract: | Budesonide is a hydrophobic glucocorticoid with high anti-inflammatory activity for the treatment of asthma, inflammatory bowel disease and rheumatoid arthritis. A micellar drug-delivery system based on lipid-DNA may provide a strategy to maximize its drug efficacy and reduce adverse effects. In this work, we report the use of lipid-DNAA (UU11mer), featuring two hydrophobic alkyl chains and forming micelles at a comparatively low critical micelle concentration, to render budesonide water-soluble with a high loading capacity (LC). The inhibition of interleukin-8 (IL-8) release shows that the new delivery system retains the inhibitory activity in cell-based assays. In conclusion, this research provides a novel approach to formulate and administer budesonide in a non-invasive manner, which dramatically improves its water-solubility while retaining its bioavailability. |
DOI of the first publication: | 10.1016/j.ejpb.2018.06.012 |
URL of the first publication: | https://www.sciencedirect.com/science/article/abs/pii/S0939641118303126?via%3Dihub |
Link to this record: | hdl:20.500.11880/29163 http://dx.doi.org/10.22028/D291-30946 |
ISSN: | 0939-6411 1873-3441 |
Date of registration: | 15-May-2020 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Pharmazie |
Professorship: | NT - Prof. Dr. Anna Hirsch |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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