Please use this identifier to cite or link to this item: doi:10.22028/D291-30946
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Title: Delivery system for budesonide based on lipid-DNA
Author(s): Liu, Yun
Bos, I. Sophie T.
Oenema, Tjitske A.
Meurs, Herman
Maarsingh, Harm
Hirsch, Anna
Language: English
Title: European journal of pharmaceutics and biopharmaceutics : EJPB
Volume: 130
Startpage: 123
Endpage: 127
Publisher/Platform: Elsevier
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Budesonide is a hydrophobic glucocorticoid with high anti-inflammatory activity for the treatment of asthma, inflammatory bowel disease and rheumatoid arthritis. A micellar drug-delivery system based on lipid-DNA may provide a strategy to maximize its drug efficacy and reduce adverse effects. In this work, we report the use of lipid-DNAA (UU11mer), featuring two hydrophobic alkyl chains and forming micelles at a comparatively low critical micelle concentration, to render budesonide water-soluble with a high loading capacity (LC). The inhibition of interleukin-8 (IL-8) release shows that the new delivery system retains the inhibitory activity in cell-based assays. In conclusion, this research provides a novel approach to formulate and administer budesonide in a non-invasive manner, which dramatically improves its water-solubility while retaining its bioavailability.
DOI of the first publication: 10.1016/j.ejpb.2018.06.012
URL of the first publication:
Link to this record: hdl:20.500.11880/29163
ISSN: 0939-6411
Date of registration: 15-May-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Anna Hirsch
Collections:UniBib – Die Universitätsbibliographie

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