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doi:10.22028/D291-30952
Title: | Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine |
Author(s): | Monjas, Leticia Swier, Lotteke J. Y. M. Setyawati, Inda Slotboom, Dirk J. Hirsch, Anna |
Language: | English |
Title: | ChemMedChem : chemistry enabling drug discovery |
Volume: | 12 |
Issue: | 20 |
Startpage: | 1693 |
Endpage: | 1696 |
Publisher/Platform: | Wiley-VCH |
Year of Publication: | 2017 |
Publikation type: | Journal Article |
Abstract: | We applied dynamic combinatorial chemistry (DCC) to identify ligands of ThiT, the S-component of the energy-coupling factor (ECF) transporter for thiamine in Lactococcus lactis. We used a pre-equilibrated dynamic combinatorial library (DCL) and saturation-transfer difference (STD) NMR spectroscopy to identify ligands of ThiT. This is the first report in which DCC is used for fragment growing to an ill-defined pocket, and one of the first reports for its application with an integral membrane protein as target. |
DOI of the first publication: | 10.1002/cmdc.201700440 |
URL of the first publication: | https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201700440 |
Link to this record: | hdl:20.500.11880/29159 http://dx.doi.org/10.22028/D291-30952 |
ISSN: | 1860-7187 1860-7179 |
Date of registration: | 15-May-2020 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Pharmazie |
Professorship: | NT - Prof. Dr. Anna Hirsch |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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