Please use this identifier to cite or link to this item: doi:10.22028/D291-30952
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Title: Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine
Author(s): Monjas, Leticia
Swier, Lotteke J. Y. M.
Setyawati, Inda
Slotboom, Dirk J.
Hirsch, Anna
Language: English
Title: ChemMedChem : chemistry enabling drug discovery
Volume: 12
Issue: 20
Startpage: 1693
Endpage: 1696
Publisher/Platform: Wiley-VCH
Year of Publication: 2017
Publikation type: Journal Article
Abstract: We applied dynamic combinatorial chemistry (DCC) to identify ligands of ThiT, the S-component of the energy-coupling factor (ECF) transporter for thiamine in Lactococcus lactis. We used a pre-equilibrated dynamic combinatorial library (DCL) and saturation-transfer difference (STD) NMR spectroscopy to identify ligands of ThiT. This is the first report in which DCC is used for fragment growing to an ill-defined pocket, and one of the first reports for its application with an integral membrane protein as target.
DOI of the first publication: 10.1002/cmdc.201700440
URL of the first publication:
Link to this record: hdl:20.500.11880/29159
ISSN: 1860-7187
Date of registration: 15-May-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Anna Hirsch
Collections:Die Universitätsbibliographie

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