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doi:10.22028/D291-30933
Title: | Energy-Coupling Factor Transporters as Novel Antimicrobial Targets |
Author(s): | Bousis, Spyridon Setyawati, Inda Diamanti, Eleonora Slotboom, Dirk J. Hirsch, Anna |
Language: | English |
Title: | Advanced therapeutics |
Volume: | 2 |
Issue: | 2 |
Publisher/Platform: | Wiley |
Year of Publication: | 2019 |
Publikation type: | Journal Article |
Abstract: | In an attempt to find new antibiotics, novel ways of interfering with important biological functions should be explored, especially with those which are necessary or even irreplaceable for bacterial survival, growth, and virulence. The purpose of this review is to highlight B‐type vitamin transporters from the energy‐coupling factor (ECF) family, which are not present in humans, as potential antimicrobial targets. In addition, a druggability analysis of an ECF transporter for folic acid and sequence‐conservation studies in seven prominent pathogens revealed new druggable pockets. Evaluation of the presence of de novo biosynthetic routes for the vitamins in question in the seven pathogens confirmed that this target class holds promise for the discovery of antimicrobial drugs with a new mechanism of action, possibly on a broad‐spectrum level. |
DOI of the first publication: | 10.1002/adtp.201800066 |
URL of the first publication: | https://onlinelibrary.wiley.com/doi/abs/10.1002/adtp.201800066 |
Link to this record: | hdl:20.500.11880/29148 http://dx.doi.org/10.22028/D291-30933 |
ISSN: | 2366-3987 |
Date of registration: | 14-May-2020 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Pharmazie |
Professorship: | NT - Prof. Dr. Anna Hirsch |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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