Please use this identifier to cite or link to this item: doi:10.22028/D291-30933
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Title: Energy-Coupling Factor Transporters as Novel Antimicrobial Targets
Author(s): Bousis, Spyridon
Setyawati, Inda
Diamanti, Eleonora
Slotboom, Dirk J.
Hirsch, Anna
Language: English
Title: Advanced therapeutics
Volume: 2
Issue: 2
Startpage: 1
Endpage: 17
Publisher/Platform: Wiley-VCH
Year of Publication: 2019
Publikation type: Journal Article
Abstract: In an attempt to find new antibiotics, novel ways of interfering with important biological functions should be explored, especially with those which are necessary or even irreplaceable for bacterial survival, growth, and virulence. The purpose of this review is to highlight B‐type vitamin transporters from the energy‐coupling factor (ECF) family, which are not present in humans, as potential antimicrobial targets. In addition, a druggability analysis of an ECF transporter for folic acid and sequence‐conservation studies in seven prominent pathogens revealed new druggable pockets. Evaluation of the presence of de novo biosynthetic routes for the vitamins in question in the seven pathogens confirmed that this target class holds promise for the discovery of antimicrobial drugs with a new mechanism of action, possibly on a broad‐spectrum level.
DOI of the first publication: 10.1002/adtp.201800066
URL of the first publication: https://onlinelibrary.wiley.com/doi/abs/10.1002/adtp.201800066
Link to this record: hdl:20.500.11880/29148
http://dx.doi.org/10.22028/D291-30933
ISSN: 2366-3987
Date of registration: 14-May-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Anna Hirsch
Collections:UniBib – Die Universitätsbibliographie

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