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doi:10.22028/D291-30930
Title: | Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol |
Author(s): | Hartman, Alwin M. Gierse, Robin M. Hirsch, Anna |
Language: | English |
Title: | European journal of organic chemistry : EurJOC |
Volume: | 2019 |
Issue: | 22 |
Startpage: | 3581 |
Endpage: | 3590 |
Publisher/Platform: | Wiley-VCH |
Year of Publication: | 2019 |
Publikation type: | Journal Article |
Abstract: | Dynamic combinatorial chemistry (DCC) is a powerful tool to identify bioactive compounds. This efficient technique allows the target to select its own binders and circumvents the need for synthesis and biochemical evaluation of all individual derivatives. An ever-increasing number of publications report the use of DCC on biologically relevant target proteins. This minireview complements previous reviews by focusing on the experimental protocol and giving detailed examples of essential steps and factors that need to be considered, such as protein stability, buffer composition and cosolvents. |
DOI of the first publication: | 10.1002/ejoc.201900327 |
URL of the first publication: | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.201900327 |
Link to this record: | hdl:20.500.11880/29145 http://dx.doi.org/10.22028/D291-30930 |
ISSN: | 1099-0690 1434-193X |
Date of registration: | 14-May-2020 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Pharmazie |
Professorship: | NT - Prof. Dr. Anna Hirsch |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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