Please use this identifier to cite or link to this item: doi:10.22028/D291-30930
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Title: Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol
Author(s): Hartman, Alwin M.
Gierse, Robin M.
Hirsch, Anna
Language: English
Title: European journal of organic chemistry : EurJOC
Volume: 2019
Issue: 22
Startpage: 3581
Endpage: 3590
Publisher/Platform: Wiley-VCH
Year of Publication: 2019
Publikation type: Journal Article
Abstract: Dynamic combinatorial chemistry (DCC) is a powerful tool to identify bioactive compounds. This efficient technique allows the target to select its own binders and circumvents the need for synthesis and biochemical evaluation of all individual derivatives. An ever-increasing number of publications report the use of DCC on biologically relevant target proteins. This minireview complements previous reviews by focusing on the experimental protocol and giving detailed examples of essential steps and factors that need to be considered, such as protein stability, buffer composition and cosolvents.
DOI of the first publication: 10.1002/ejoc.201900327
URL of the first publication:
Link to this record: hdl:20.500.11880/29145
ISSN: 1099-0690
Date of registration: 14-May-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Anna Hirsch
Collections:UniBib – Die Universitätsbibliographie

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