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doi:10.22028/D291-30927
Title: | Flotillin mediated membrane fluidity controls peptidoglycan synthesis and MreB movement |
Author(s): | Zielińska, Aleksandra Savietto, Abigail de Sousa Borges, Anabela Martinez, Denis Berbon, Melanie Roelofsen, Joël R. Hartman, Alwin M. de Boer, Rinse van der Klei, Ida J. Hirsch, Anna Habenstein, Birgit Bramkamp, Marc Scheffers, Dirk-Jan |
Language: | English |
Publisher/Platform: | bioRxiv |
Year of Publication: | 2019 |
Publikation type: | Other |
Abstract: | The bacterial plasma membrane is an important cellular compartment. In recent years it has become obvious that protein complexes and lipids are not uniformly distributed within membranes. Current hypotheses suggest that flotillin proteins are required for the formation of complexes of membrane proteins including cell-wall synthetic proteins. We show here that bacterial flotillins are important factors for membrane fluidity homeostasis. Loss of flotillins leads to a decrease in membrane fluidity that in turn leads to alterations in MreB dynamics and, as a consequence, in peptidoglycan synthesis. These alterations are reverted when membrane fluidity is restored by a chemical fluidizer. In vitro, the addition of a flotillin increases membrane fluidity of liposomes. Our data support a model in which flotillins are required for direct control of membrane fluidity rather than for the formation of protein complexes via direct protein-protein interactions. |
DOI of the first publication: | 10.1101/736819 |
URL of the first publication: | https://www.biorxiv.org/content/10.1101/736819v2 |
Link to this record: | hdl:20.500.11880/29142 http://dx.doi.org/10.22028/D291-30927 |
Date of registration: | 14-May-2020 |
Notes: | Preprint |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Pharmazie |
Professorship: | NT - Prof. Dr. Anna Hirsch |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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