Please use this identifier to cite or link to this item: doi:10.22028/D291-30927
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Title: Flotillin mediated membrane fluidity controls peptidoglycan synthesis and MreB movement
Author(s): Zielińska, Aleksandra
Savietto, Abigail
de Sousa Borges, Anabela
Martinez, Denis
Berbon, Melanie
Roelofsen, Joël R.
Hartman, Alwin M.
de Boer, Rinse
van der Klei, Ida J.
Hirsch, Anna
Habenstein, Birgit
Bramkamp, Marc
Scheffers, Dirk-Jan
Language: English
Publisher/Platform: bioRxiv
Year of Publication: 2019
Publikation type: Other
Abstract: The bacterial plasma membrane is an important cellular compartment. In recent years it has become obvious that protein complexes and lipids are not uniformly distributed within membranes. Current hypotheses suggest that flotillin proteins are required for the formation of complexes of membrane proteins including cell-wall synthetic proteins. We show here that bacterial flotillins are important factors for membrane fluidity homeostasis. Loss of flotillins leads to a decrease in membrane fluidity that in turn leads to alterations in MreB dynamics and, as a consequence, in peptidoglycan synthesis. These alterations are reverted when membrane fluidity is restored by a chemical fluidizer. In vitro, the addition of a flotillin increases membrane fluidity of liposomes. Our data support a model in which flotillins are required for direct control of membrane fluidity rather than for the formation of protein complexes via direct protein-protein interactions.
DOI of the first publication: 10.1101/736819
URL of the first publication:
Link to this record: hdl:20.500.11880/29142
Date of registration: 14-May-2020
Notes: Preprint
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Anna Hirsch
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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