Please use this identifier to cite or link to this item:
doi:10.22028/D291-27519
Title: | The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data |
Author(s): | Pilz, Stefan Zittermann, Armin Obeid, Rima Hahn, Andreas Pludowski, Pawel Trummer, Christian Lerchbaum, Elisabeth Pérez-López, Faustino R. Karras, Spyridon N. März, Winfried |
Language: | English |
Title: | International Journal of Environmental Research and Public Health |
Volume: | 15 |
Issue: | 10 |
Publisher/Platform: | MDPI |
Year of Publication: | 2018 |
Free key words: | vitamin D gestational diabetes pre-eclampsia breast milk vitamin D binding protein DBP brain autism 25-hydroxyvitamin D |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Vitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the “active vitamin D hormone” calcitriol support the important role of vitamin D in this setting. Observational studies show that vitamin D deficiency is a risk marker for reduced fertility and various adverse pregnancy outcomes and is associated with a low vitamin D content of breast milk. Meta-analyses of randomized controlled trials (RCTs) document that physiological vitamin D supplementation during pregnancy is safe and improves vitamin D and calcium status, thereby protecting skeletal health. Although certain RCTs and/or meta-analyses reported some other beneficial effects, it is still not clear whether vitamin D supplementation improves fertility or decreases the risk of adverse pregnancy outcomes such as low birth weight, pre-eclampsia and neonatal mortality, or reduces wheeze/asthma in the infants. Nevertheless, vitamin D supplementation in pregnant women is frequently required to achieve a sufficient vitamin D status as recommended by nutritional vitamin D guidelines. In this review, we provide an overview of systematic reviews, meta-analyses and large trials reporting clinical data on the role of vitamin D for fertility, pregnancy and lactation. |
DOI of the first publication: | 10.3390/ijerph15102241 |
Link to this record: | urn:nbn:de:bsz:291--ds-275193 hdl:20.500.11880/28906 http://dx.doi.org/10.22028/D291-27519 |
ISSN: | 1660-4601 |
Date of registration: | 22-Mar-2020 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Innere Medizin |
Professorship: | M - Keiner Professur zugeordnet |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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ijerph-15-02241.pdf | 376,28 kB | Adobe PDF | View/Open |
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