Please use this identifier to cite or link to this item: doi:10.22028/D291-27519
Title: The Role of Vitamin D in Fertility and during Pregnancy and Lactation: A Review of Clinical Data
Author(s): Pilz, Stefan
Zittermann, Armin
Obeid, Rima
Hahn, Andreas
Pludowski, Pawel
Trummer, Christian
Lerchbaum, Elisabeth
Pérez-López, Faustino R.
Karras, Spyridon N.
März, Winfried
Language: English
Title: International Journal of Environmental Research and Public Health
Volume: 15
Issue: 10
Publisher/Platform: MDPI
Year of Publication: 2018
Free key words: vitamin D
gestational diabetes
breast milk
vitamin D binding protein
25-hydroxyvitamin D
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Vitamin D deficiency is common and there exists a huge gap between recommended dietary vitamin D intakes and the poor vitamin D supply in the general population. While vitamin D is important for musculoskeletal health, there are accumulating data suggesting that vitamin D may also be important for fertility, pregnancy outcomes and lactation. Significant changes in vitamin D metabolism during pregnancy such as increased production of the “active vitamin D hormone” calcitriol support the important role of vitamin D in this setting. Observational studies show that vitamin D deficiency is a risk marker for reduced fertility and various adverse pregnancy outcomes and is associated with a low vitamin D content of breast milk. Meta-analyses of randomized controlled trials (RCTs) document that physiological vitamin D supplementation during pregnancy is safe and improves vitamin D and calcium status, thereby protecting skeletal health. Although certain RCTs and/or meta-analyses reported some other beneficial effects, it is still not clear whether vitamin D supplementation improves fertility or decreases the risk of adverse pregnancy outcomes such as low birth weight, pre-eclampsia and neonatal mortality, or reduces wheeze/asthma in the infants. Nevertheless, vitamin D supplementation in pregnant women is frequently required to achieve a sufficient vitamin D status as recommended by nutritional vitamin D guidelines. In this review, we provide an overview of systematic reviews, meta-analyses and large trials reporting clinical data on the role of vitamin D for fertility, pregnancy and lactation.
DOI of the first publication: 10.3390/ijerph15102241
Link to this record: urn:nbn:de:bsz:291--ds-275193
ISSN: 1660-4601
Date of registration: 22-Mar-2020
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Files for this record:
File Description SizeFormat 
ijerph-15-02241.pdf376,28 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons