Please use this identifier to cite or link to this item: doi:10.22028/D291-30506
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Title: AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticulum
Author(s): Klein, Marie-Christine
Zimmermann, Katharina
Schorr, Stefan
Landini, Martina
Klemens, Patrick A. W.
Altensell, Jacqueline
Jung, Martin
Krause, Elmar
Nguyen, Duy
Helms, Volkhard
Rettig, Jens
Fecher-Trost, Claudia
Cavalié, Adolfo
Hoth, Markus
Bogeski, Ivan
Neuhaus, H Ekkehard
Zimmermann, Richard
Lang, Sven
Haferkamp, Ilka
Language: English
Title: Nature Communications
Volume: 9
Issue: 1
Publisher/Platform: Nature Publishing Group UK
Year of Publication: 2018
Publikation type: Journal Article
Abstract: To fulfill its role in protein biogenesis, the endoplasmic reticulum (ER) depends on the Hsp70-type molecular chaperone BiP, which requires a constant ATP supply. However, the carrier that catalyzes ATP uptake into the ER was unknown. Here, we report that our screen of gene expression datasets for member(s) of the family of solute carriers that are co-expressed with BiP and are ER membrane proteins identifies SLC35B1 as a potential candidate. Heterologous expression of SLC35B1 in E. coli reveals that SLC35B1 is highly specific for ATP and ADP and acts in antiport mode. Moreover, depletion of SLC35B1 from HeLa cells reduces ER ATP levels and, as a consequence, BiP activity. Thus, human SLC35B1 may provide ATP to the ER and was named AXER (ATP/ADP exchanger in the ER membrane). Furthermore, we propose an ER to cytosol low energy response regulatory axis (termed lowER) that appears as central for maintaining ER ATP supply.
DOI of the first publication: 10.1038/s41467-018-06003-9
URL of the first publication:
Link to this record: hdl:20.500.11880/28886
ISSN: 2041-1723
Date of registration: 20-Mar-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Volkhard Helms
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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